Lumakras (Sotorasib) is a prescription oral medication used to treat adults with non-small cell lung cancer (NSCLC) that has a specific KRAS G12C mutation. It is typically prescribed when the cancer has spread or cannot be surgically removed and after the patient has received at least one prior therapy. Lumakras (Sotorasib) targets cancer cells by inhibiting the KRAS G12C protein, which plays a role in tumor growth.
Without insurance, Lumakras (Sotorasib) can be extremely expensive, with U.S. retail prices exceeding $5,200 per month.
Key Takeaways
Online Pharmacies Offer Major Savings: CIPA-certified pharmacies like DrugMart list Lumakras (Sotorasib) at ~$12,155 for a 240-tablet pack (120 mg), a savings of more than 60% compared to U.S. pharmacies. Order directly from DrugMart.com.
U.S. Pharmacies Charge $5,208–$5,484 Monthly: Major U.S. retailers including CVS, Walgreens, and Target list Lumakras (Sotorasib) near or above $5,200 per 30-day supply.
Lumakras Is Covered by Medicare and Private Insurance: It is usually placed on Tier 5 of Medicare formularies, meaning prior authorization and high coinsurance may apply.
Cheapest Online Pharmacies for Lumakras (Sotorasib)
Places to purchase Lumakras (Sotorasib) online:
Pharmacy | Prescription Required | Price (30 Tablets) | Dosage | Website |
DrugMart | Yes | $1,519.45 | 120mg | |
Planet Drugs Direct | Yes | $1,519.50 | 120mg | |
BlinkHealth | Yes | $2,762.63 | 120mg |
Prices as of July 1, 2025. May vary by location, quantity, and shipping origin.
U.S. Retail Prices for Lumakras (Sotorasib)
U.S. retail prices for Lumakras (Sotorasib):
Pharmacy | Retail Price (30-Day Supply) |
Stop and Shop | $5,208.78 |
Walgreens | $5,238.30 |
CVS Pharmacy | $5,383.89 |
Target (CVS) | $5,483.89 |
Prices as of July 1, 2025. Actual costs may vary based on insurance and location.
How to Save on Lumakras (Sotorasib)
Here’s how to save on Lumakras (Sotorasib):
1. Use Medicare Part D or Commercial Insurance
Lumakras is typically covered under Medicare Part D and most private insurance plans. It is often placed on Tier 5, which has the highest coinsurance.
Tip: Use the Medicare Plan Finder or your insurance portal to check coverage and out-of-pocket estimates.
2. Amgen FIRST STEP™ and Assist 360™ Programs
Amgen offers financial assistance for Lumakras:
FIRST STEP™: Eligible commercially insured patients may pay as little as $0 for each dose.
Assist 360™: Support for patients with Medicare or government insurance, including help locating nonprofit copay foundations and applying for aid.
Visit: www.amgensupportplus.com/lumakras or call 1-888-427-7478.
3. CIPA-Certified Online Pharmacies
International pharmacies may offer up to 60% savings on Lumakras (Sotorasib) if you purchase a 30- or 240-tablet supply with a prescription.
Ready to purchase? Order from DrugMart.
Common Questions About Lumakras (Sotorasib)
Common questions and answers about Lumakras (Sotorasib):
1. Is Lumakras (Sotorasib) covered by Medicare?
Yes. Most Medicare Part D plans cover Lumakras, but it is usually on Tier 5, which involves high coinsurance and often requires prior authorization. Your final out-of-pocket cost depends on the phase of your coverage.
2. Are there savings programs for Lumakras (Sotorasib)?
Yes. Amgen offers both the FIRST STEP™ and Assist 360™ programs. These help reduce or eliminate copays for eligible insured patients and guide Medicare patients toward third-party foundations for assistance.
3. How much will Lumakras (Sotorasib) cost per year?
Here’s how much Lumakras (Sotorasib) could cost per year, depending on your dosing schedule:
Purchase Method | Monthly Estimate | Annual Estimate |
U.S. Retail Pharmacies | $5,208 – $5,484 | $62,496 – $65,808 |
CIPA-Certified Online Pharmacy | ~$12,155 / 240 | ~$1,518/month* |
Medicare Part D (out-of-pocket cap) | Up to $2,000 | $2,000 (2025 cap) |
Amgen FIRST STEP (Commercial Plans) | As low as $0 | Varies by plan |
Based on prorated 240-tablet pricing. Usage depends on the physician’s dosing schedule.
4. Why is Lumakras (Sotorasib) so expensive?
Multiple factors drive up the cost of Lumakras (Sotorasib):
High Development Costs: Cancer drugs undergo rigorous R&D and clinical trials before FDA approval, which raises launch prices.
Limited Competition: Lumakras treats a specific genetic mutation (KRAS G12C), with few direct therapeutic competitors.
No Generic Equivalent: Without generics, Amgen retains pricing power under brand-name exclusivity.
Complex Manufacturing: Precision oncology drugs like Lumakras require advanced formulation and quality control.
Cancer Market Pricing: Oncology drugs are often priced higher due to their role in extending survival in life-threatening conditions.
CIPA-Certified Canadian Pharmacies Provide Safe, Effective Prescription Drugs https://Drugmart.com is a CIPA-member Canadian prescription referral service with hundreds of medications at incredible savings. We source from reputable pharmacies located in the United Kingdom, New Zealand, Australia and Canada. We offer non-prescription Canada drugs and pet medications, too!
Rest assured, even though you may receive your medication from a country other than Canada, because your order is placed through https://Drugmart.com - which is a CIPA sanctioned seller - it's just as safe as if it were shipped directly from our Canadian pharmacy.
If you need expert advice, https://Drugmart.com can connect you with a team of licensed pharmacists to address your concerns. Our customer service team will help with any questions you may have. You can also check out our list of FAQs to get answers to the most-asked questions we receive. Find your prescription, create an account and start saving on your meds from https://Drugmart.com today!
Sources
U.S. Food and Drug Administration. Lumakras® (sotorasib) Prescribing Information [PDF]. Revised 2022. Accessed July 2, 2025. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/214665s002lbl.pdf
Amgen Inc. Lumakras® NSCLC Patient Support Resources. Accessed July 2, 2025. https://www.lumakras.com/nsclc/support
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