Xtandi (Enzalutamide) is a prescription oral medication used to treat prostate cancer that is metastatic and/or resistant to standard hormone therapy. It works by blocking the effects of androgens (male hormones), which fuel the growth of prostate cancer cells. Xtandi is often used in combination with other therapies and is typically taken daily in capsule form.
Without insurance, Xtandi (Enzalutamide) can be extremely costly, with U.S. retail pharmacy prices ranging from $14,973 to over $15,000 per month.
Key Takeaways
Online Pharmacies Offer Major Savings: International, CIPA-certified pharmacies like DrugMart list Xtandi (Enzalutamide) at $4,842.61 for a 112-capsule supply—equivalent to roughly $1,297 per month—offering a discount of over 85% compared to many U.S. retail prices. Purchase from DrugMart.com
U.S. Pharmacies Charge $14,973+ Monthly Without Insurance: Blink Health and other major retailers list Xtandi (Enzalutamide) at nearly $15,000 for a 30-day supply.
Xtandi Is Covered by Medicare and Private Insurance: Xtandi is widely covered, with nearly all Medicare Part D plans listing it on formulary. However, it is usually placed on high-cost specialty tiers and may require prior authorization.
Cheapest Online Pharmacies for Xtandi (Enzalutamide)
Cheapest online pharmacies to purchase your Xtandi (Enzalutamide) prescription:
Pharmacy | Prescription Required | Price (30 Capsules) | Dosage | Website |
DrugMart | Yes | ~$1,297.36 (prorated) | 40mg | |
Planet Drugs Direct | Yes | ~$1,514.64 (prorated) | 40mg | |
Blink Health | Yes | $14,973.40 | 40mg |
Prices as of July 1, 2025. May vary by quantity, shipping, and country of origin.
U.S. Retail Prices for Xtandi (Enzalutamide)
Estimated U.S. retail pharmacy prices for Xtandi (Enzalutamide):
Pharmacy | Retail Price (30-day Supply) |
Blink Health | $14,973.40 |
Other U.S. Retailers | $14,500 – $15,000+ (typical) |
Prices as of July 1, 2025. May vary by location and insurance status.
How to Save on Xtandi (Enzalutamide)
Here’s how to save on your Xtandi (Enzalutamide) prescription:
1. Use Medicare Part D or Commercial Insurance
Xtandi is widely covered under Medicare Part D and Medicare Advantage plans. It is typically placed on a specialty tier (Tier 5), meaning high coinsurance and prior authorization requirements may apply.
Tip: Medicare beneficiaries in 2025 may benefit from new annual out-of-pocket caps (maximum $2,000 for the year), along with the option to spread prescription costs evenly throughout the year via a payment plan.
2. Xtandi Copay Assistance and Patient Support Programs
XTANDI Patient Savings Program
For commercially insured patients
Pay as little as $0 per prescription
Annual maximum copay assistance up to $7,000
Valid for a 12-month period; no income requirements
Phone: 1-855-217-8311 | View PDF
XTANDI Support Solutions
Personalized insurance benefit review
Prior authorization support
Connections to patient assistance programs for uninsured or underinsured individuals
Education and ongoing adherence resources
3. CIPA-Certified Online Pharmacies
Patients without insurance or with high deductible plans may consider ordering from licensed international pharmacies, which can reduce monthly costs by over 80%. Valid prescription required.
Ready to purchase? Order from DrugMart.com
Common Questions About Xtandi (Enzalutamide)
Common questions and answers about Xtandi (Enzalutamide):
1. Is Xtandi (Enzalutamide) covered by Medicare?
Yes. Xtandi is covered by nearly all Medicare Part D plans (99% coverage). It typically appears on the specialty tier (Tier 5), and prior authorization is often required. In 2025, the new $2,000 out-of-pocket maximum under Medicare Part D could substantially reduce total yearly costs for Xtandi.
2. Can I use the Xtandi copay savings card with Medicare?
No. The XTANDI Patient Savings Program is only available to patients with private commercial insurance. Patients on Medicare, Medicaid, or other government-funded health programs are not eligible.
3. How much will Xtandi (Enzalutamide) cost per year?
Here’s how much Xtandi (Enzalutamide) could cost per year:
Purchase Method | Monthly Estimate | Annual Estimate |
U.S. Retail Pharmacies | $14,973 – $15,000 | $179,676 – $180,000 |
CIPA Online Pharmacy (DrugMart) | ~$1,297 (prorated) | ~$15,568 |
Medicare Part D (2025 cap) | $2,000 maximum | $2,000 |
Purchase Your Over-the-Counter and Prescription Drugs From https://Drugmart.com You can rely on https://Drugmart.com for over-the-counter and prescription drugs at a discount. We're a leading referral service for patients who want to order medications from Canada online and other international partners, offering unparalleled customer service. If you have any questions, be sure to contact our outstanding customer service representatives for the answers you need.
Sources
Astellas Pharma US, Inc. and Pfizer Inc. XTANDI Copay Assistance Patient Brochure [PDF]. Accessed July 1, 2025. https://www.xtandi.com/pdf/xtandi-copay-patient-brochure.pdf
Astellas Pharma US, Inc. and Pfizer Inc. XTANDI Medicare Part D IRA Flash Card (2025) [PDF]. Accessed July 1, 2025. https://www.xtandi.com/pdf/pm-xtandi-consumer-medicare-part-d-ira-may-pay-less-flash-card-electronic_2025.pdf
U.S. Food and Drug Administration. XTANDI (enzalutamide) Prescribing Information [PDF]. Revised July 2018. Accessed July 1, 2025. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/203415s014lbl.pdf
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