Mavenclad (Cladribine) is an oral prescription medication used to treat relapsing forms of multiple sclerosis (MS), including relapsing-remitting MS (RRMS) and active secondary progressive MS (SPMS). It is a disease-modifying therapy (DMT) that works by selectively targeting certain white blood cells involved in the immune system’s attack on the nervous system, helping to reduce relapses and slow disease progression.
Without insurance, Mavenclad (Cladribine) can be prohibitively expensive, with U.S. retail pharmacy prices ranging from $72,626 to over $83,500 per treatment cycle.
Key Takeaways
Online Pharmacies Offer Major Savings: International, CIPA-certified pharmacies such as DrugMart list Mavenclad (Cladribine) at $49,024.07 for a 10-tablet pack, compared to U.S. retail prices exceeding $70,000 per cycle—a savings of more than 30%. Purchase from DrugMart.com
U.S. Pharmacies Charge $72,626–$83,521 Without Insurance: Major retailers like Walgreens, Walmart, and Costco list Mavenclad (Cladribine) well above $72,000 per cycle.
Mavenclad Is Covered by Medicare and Many Private Insurers: Mavenclad is typically placed on specialty tiers, and coverage often requires prior authorization. Out-of-pocket costs vary based on the insurance plan’s deductible and phase of coverage.
Cheapest Online Pharmacies for Mavenclad (Cladribine)
Cheapest online pharmacies to purchase Mavenclad (Cladribine):
Pharmacy | Prescription Required | Price (10 Tablets) | Dosage | Website |
DrugMart | Yes | $49,024.07 | 40mg | |
Planet Drugs Direct | Yes | $56,354.99 | 10mg | |
Blink Health | Yes | $108,668.04 | 10mg |
Prices as of July 1, 2025. May vary by quantity, shipping, and country of origin.
U.S. Retail Prices for Mavenclad (Cladribine)
Average U.S. retail prices for Mavenclad (Cladribine):
Pharmacy | Retail Price (1 Cycle) |
Meijer Pharmacy | $72,626 |
Aurora Pharmacy | $73,217 |
Capsule Pharmacy | $74,447 |
Jewel-Osco | $76,260 |
Walgreens / Walgreens Specialty | $77,440 |
Walmart / Neighborhood Market | $78,074 |
Mariano’s | $79,891 |
Costco | $83,521 |
Prices as of July 1, 2025. Actual prices may vary by location, availability, and pharmacy.
How to Save on Mavenclad (Cladribine)
Here’s how to save on your Mavenclad (Cladribine) prescription:
1. Use Medicare Part D or Commercial Insurance
Mavenclad is covered under many Medicare Part D and private insurance plans. However, it is often listed on specialty tiers, and prior authorization is commonly required.
Tip: Use Medicare Plan Finder or your insurance portal to check coverage and get an estimate of out-of-pocket costs. In 2025, Medicare caps annual out-of-pocket costs at $2,000 for prescription drugs, which may apply to Mavenclad depending on plan details.
2. Patient Assistance and Copay Programs
MS LifeLines by EMD Serono
Offers copay assistance for eligible patients
May provide free medication for uninsured or underinsured patients based on income
Includes nurse support, education, and reimbursement guidance
To learn more, visit MS LifeLines
3. CIPA-Certified Online Pharmacies
Buying Mavenclad from a licensed Canadian or international pharmacy can save patients over 30%. A valid prescription is required. Medications are typically shipped from regulated pharmacies in Canada, the UK, or Australia.
Ready to purchase? Order from DrugMart.com
Common Questions About Mavenclad (Cladribine)
Common questions and answers about Mavenclad (Cladribine):
1. Is Mavenclad (Cladribine) covered by Medicare?
Yes. Medicare Part D plans typically cover Mavenclad. However, it may require prior authorization and is commonly placed on a specialty tier with higher cost-sharing requirements. The patient’s costs will depend on their plan’s deductible and coverage phase.
2. Are there any savings programs for Mavenclad?
Yes. EMD Serono offers MS LifeLines, a patient support program that provides financial assistance for both insured and uninsured individuals. Eligible commercially insured patients may pay as little as $0 per prescription, and income-based support is available for others.
3. How much will Mavenclad (Cladribine) cost per year?
Mavenclad is administered in two annual treatment courses over a two-year period, not continuously every month like many other MS drugs. Each annual course consists of 2 treatment weeks (1 week per month for 2 months), with a total of 8 to 10 days of medication per year depending on body weight.
Here’s how that breaks down:
Purchase Method | Annual Dose Estimate | Annual Cost Estimate |
U.S. Retail Pharmacies | ~10 tablets/year | $72,626 – $83,521 |
CIPA-certified Online Pharmacy (DrugMart) | ~10 tablets/year | ~$49,024 |
Medicare Part D (2025 cap) | Max out-of-pocket = $2,000 | $2,000 |
Total Cost Over 2-Year Treatment:
Retail (U.S.): $145,252 – $167,042
CIPA-certified online pharmacy: ~$98,048
Medicare (2025): $2,000 (due to annual out-of-pocket cap)
Patients do not take Mavenclad continuously in years 3 and beyond unless clinically indicated, which further impacts long-term cost expectations. Always consult your neurologist or MS specialist for personalized treatment planning.
4. Why is Mavenclad (Cladribine) so expensive?
Several factors contribute to the high cost of Mavenclad:
Research and Development (R&D) Costs: Developing a new drug requires substantial investment in laboratory research, clinical trials, and regulatory approval. These costs, including failures of other drug candidates, are factored into Mavenclad’s pricing.
Patent Protection and Market Exclusivity: Mavenclad is protected by patents that prevent generic competition. A key patent related to progressive MS treatment extends until 2038, allowing the manufacturer, EMD Serono Inc., to maintain premium pricing.
Market Demand and Perceived Value: Mavenclad offers a unique treatment approach for relapsing-remitting MS, with a two-course dosing regimen over two years. Its ability to reduce relapses and potentially slow progression makes it highly valued in the MS treatment landscape.
Complex Manufacturing and Distribution: As a specialty medication, Mavenclad involves advanced manufacturing processes and quality control, as well as a tightly managed supply chain to ensure safety and efficacy.
Lack of Generic Alternatives: Currently, no generic version of Mavenclad is available. Without competition from lower-cost generics, the manufacturer can sustain higher list prices.
While the U.S. list price for a 10mg tablet is estimated around $3,082.70, Mavenclad is not taken monthly. It is administered in two treatment courses over two years, and actual out-of-pocket costs may be significantly reduced through insurance coverage or patient assistance programs.
Find Affordable Brand-Name and Generic Drugs at Drugmart.com At Drugmart.com, we pride ourselves on our affordability, exceptional quality and ease of use when our patients shop for both brand-name and generic drugs. We work closely with the world's most reputable pharmacies to provide high-quality medications from Canada and other tier 1 international sources at unmatched prices, so you can get the treatment you need without worrying about affordability.
Sources
Merck KGaA. Mavenclad® Patient Support Resources. Accessed July 2, 2025. https://www.mavenclad.com/en/home/support-resources/support.html
U.S. Food and Drug Administration. Mavenclad (cladribine) Prescribing Information [PDF]. Revised August 2019. Accessed July 2, 2025. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/022561s000lbl.pdf
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