Retin-A Cream (tretinoin) is a topical retinoid derived from vitamin A that promotes skin cell turnover. It is commonly prescribed for the treatment of acne, photoaging (wrinkles, fine lines, dark spots), and other dermatological conditions. Tretinoin works by stimulating rapid cell regeneration and exfoliation, which helps unclog pores, reduce inflammation, and improve skin texture over time. It is available in multiple concentrations, but 0.05% is one of the most frequently prescribed.
Key Takeaways
Availability: Retin-A Cream (tretinoin 0.05%) is available by prescription from certified online pharmacies. DrugMart currently offers the lowest price for a 60g tube at $87.86. Unlike some online pharmacies and providers, it does not require a bundled telehealth consultation, helping to reduce out-of-pocket expenses.
How It Works: Tretinoin increases epidermal cell turnover, helping to prevent clogged pores, smooth rough skin, and lighten hyperpigmentation. It is a gold standard treatment in dermatology for acne and aging-related skin concerns.
Common Side Effects: Initial use may cause dryness, redness, peeling, or increased sun sensitivity. Serious reactions like blistering or excessive irritation should prompt medical evaluation.
3 Best Places to Buy Retin-A Cream (Tretinoin) Online
Retin-A (tretinoin) is a topical treatment used to address moderate to severe acne, fine wrinkles, skin discoloration, and rough skin. It is part of a class of medications called retinoids, which act directly on retinoic acid receptors in the skin to enhance cell turnover and stimulate collagen production. Here are the three best online pharmacies to purchase your prescription:
Provider | Price (60g) | Prescription Required | Strength | Website |
DrugMart | $87.86 | Yes | 0.05% | |
Planet Drugs Direct | $93.99 | Yes | 0.05% | |
TelyRX | $129.98 | Yes | 0.05% |
Prices updated as of April 5, 2025. Prices may change based on strength, date, and other key factors in your purchase.
Where to Buy Retin-A Cream (Tretinoin 0.05%) Online
1. DrugMart
CIPA-certified international pharmacy offering one of the lowest prices for Retin-A Cream (tretinoin 0.05%). No bundled telehealth consultation required, making it a cost-effective option for those with an existing prescription.
Price: $87.86 for 60g (0.05%)
Prescription Required: Yes
Consultation Included: No
2. PlanetDrugsDirect
Reputable international pharmacy with CIPA certification offering Retin-A Cream at a competitive price. Prescription required but no added consultation or service fees.
Price: $93.99 for 60g (0.05%)
Prescription Required: Yes
Consultation Included: No
3. TelyRX
U.S.-based telehealth and pharmacy platform offering Retin-A Cream at a higher price point, but may include bundled prescription services depending on patient needs.
Price: $129.98 for 60g (0.05%)
Prescription Required: Yes
Consultation Included: May be included (check provider terms)
What is Retin-A (Tretinoin)?
Retin-A is a topical form of vitamin A that promotes skin cell turnover. It is primarily used to treat acne and photoaging-related conditions.
Retin-A and Avita brands are indicated for the treatment of acne.
Renova is prescribed to reduce the appearance of fine wrinkles, skin discoloration, and rough facial texture due to sun damage.
Retin-A may also be used for other dermatological conditions as determined by your provider.
Warnings
Photosensitivity: Retin-A increases your skin’s sensitivity to sunlight and UV radiation. Avoid sun exposure, tanning beds, and use a broad-spectrum SPF (15 or higher) daily.
Irritation risk: Do not apply Retin-A to sunburned, windburned, chapped, broken, or irritated skin. Avoid the eyes, nostrils, mouth, and mucous membranes.
Initial Worsening: Acne may appear worse during the first few weeks of use before improvement begins.
Persistence required: It may take 8–12 weeks for significant improvement. Continue using Retin-A exactly as prescribed even if early results are not visible.
Before Using Retin-A
Do not use Retin-A if:
You are allergic to tretinoin or related retinoids.
Inform your doctor if you:
Are pregnant or planning pregnancy (risk is undetermined)
Are breastfeeding (safety during lactation is not fully established)
How to Use Retin-A
Apply exactly as prescribed, usually once daily at bedtime.
Wash hands and cleanse skin with mild soap. Allow skin to dry completely (wait 20–30 minutes) before application to reduce irritation.
Apply a thin layer and avoid contact with sensitive areas.
Do not wash the treated area for at least 1 hour after application.
Avoid excessive application, which can increase side effects and cause "pilling."
Important: Retin-A is flammable. Avoid open flames or smoking until fully dry.
Missed Dose & Overdose
Missed dose: Apply as soon as remembered. Skip if it’s close to the next dose—do not double up.
Overdose: Though unlikely from topical use, contact a poison control center or your provider if accidental ingestion occurs.
What to Avoid
Direct sunlight or UV exposure. Always wear protective clothing and SPF 30+ sunscreen.
Harsh or drying skin products (alcohol-based, exfoliants, medicated shampoos, etc.)
Applying other topical medications to the same area unless directed by a healthcare provider.
Side Effects
Seek emergency care if you experience signs of an allergic reaction:
Hives
Difficulty breathing
Swelling of face, lips, tongue, or throat
Stop use and contact your doctor if you experience:
Severe burning, redness, blistering, or peeling
Significant irritation that worsens over time
Common (mild) side effects:
Warmth, stinging, or mild redness
Temporary changes in skin pigmentation
Peeling or dryness
Your skin may become more sensitive to wind and cold while using Retin-A.
Drug Interactions
Avoid using Retin-A in combination with:
Harsh soaps or cleansers
Alcohol-based or medicated products (e.g., benzoyl peroxide unless directed)
Other topical acne or wrinkle treatments without provider approval
For complete safety and prescribing information, consult your healthcare provider or visit FDA.gov.
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Sources
U.S. Food and Drug Administration. Retin-A (tretinoin) Cream, 0.05% – Prescribing Information. Silver Spring, MD: FDA; 2002. Accessed May 1, 2025. https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/16921s21s22s25lbl.pdf
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