(Rivaroxaban)
Prescription required. Can not be split. Product of Australia. Shipped from Australia.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom.
Prescription required. Can not be split. Product of New Zealand. Shipped from New Zealand.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom.
Prescription required. Can not be split. Product of New Zealand. Shipped from New Zealand.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom. Xarelto is also marketed internationally under the name Xarelto Treatment Initiation Pack.
Prescription required. Can not be split. Product of New Zealand. Shipped from New Zealand.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom.
Xarelto (rivaroxaban) is a direct oral anticoagulant (DOAC) that works by inhibiting Factor Xa, an enzyme crucial for blood clot formation. It is widely prescribed to reduce the risk of stroke, deep vein thrombosis (DVT), pulmonary embolism (PE), and other clot-related conditions. Xarelto is an oral, once-daily blood thinner that often requires less frequent monitoring when compared with alternatives like warfarin.
Atrial Fibrillation (non-valvular): To reduce the risk of stroke and systemic embolism (blood clot formation).
Deep Vein Thrombosis (DVT): Treatment and prevention of recurrent blood clots in areas of the body like the legs.
Pulmonary Embolism (PE): Treatment and long-term prevention of blood clots that travel to and damage the lungs.
Post-Surgical DVT Prevention: After hip or knee replacement surgery.
Coronary Artery Disease (CAD) or Peripheral Artery Disease (PAD): To reduce cardiovascular risk, often in combination with aspirin.
Venous Thromboembolism (VTE) in Children: For pediatric patients aged 2+ (weight-based dosing).
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Xarelto helps prevent and treat blood clots by:
Blocking the activity of Factor Xa, interrupting the clotting cascade.
Reducing the risk of stroke in atrial fibrillation patients.
Offering convenience over routine INR checks required for warfarin.
Supporting recovery after orthopedic surgery or cardiovascular procedures.
Atrial Fibrillation: 20 mg once daily with evening meal (15 mg for reduced kidney function).
DVT/PE Treatment: 15 mg twice daily for 21 days, then 20 mg once daily.
Coronary Artery Disease/Peripheral Artery Disease: 2.5 mg twice daily with aspirin (81 mg) once daily.
Post-Surgical Prevention of blood clots: 10 mg once daily.
Pediatric Use (VTE): Weight-based; tablet or liquid formulation available.
Take tablets with food (particularly important for pediatric patients, as it increases the reliability of absorption). Swallow whole; do not split or crush unless instructed.
Managing a missed dose is different depending on your current stage of treatment. For treatment of an existing clot (often dosed twice daily), taking both tablets at once may be recommended to ensure you receive the full daily dose. For long-term prevention of clots, doses should not be doubled up. In general, your provider may recommend:
For once-daily doses: Take as soon as remembered; skip if close to the next dose.
For twice-daily doses: Take both tablets in one dose if a dose is missed.
Always consult your healthcare providers for personalized advice, as missing a dose or doubling up on a dose may cause significant risks.
Seek emergency medical care or contact Poison Help at 1-800-222-1222 in the US or 1-844-764-7669 in Canada.
The primary concern when taking blood thinners like Xarelto is an increased risk of bleeding. In some instances, bleeding may be serious or life-threatening. Always discuss ways to manage your risks with your healthcare providers to help promote safety.
Bleeding (nosebleeds, gum bleeding, bruising)
Abdominal pain
Fatigue
Muscle spasms
Back pain
Dizziness
Mood changes
Severe or prolonged bleeding
Blood in urine or stool (may sometimes appear dark or tarry if the blood has already clotted while traveling through the digestive tract—common in upper GI bleeds like stomach ulcers)
Coughing up blood
Sudden severe headaches (possible brain bleed)
Vision changes, weakness, or numbness
Spinal or epidural hematoma (especially with spinal procedures)
Do NOT take Xarelto if:
You are actively bleeding or have a bleeding disorder
You are allergic to rivaroxaban or other inactive ingredients
You have severe liver disease with associated clotting risk
Use With Caution If You Have:
Kidney or liver impairment
History of gastrointestinal ulcers or recent bleeding
Upcoming spinal procedures or use of spinal/epidural catheters
Combined use with other anticoagulants or antiplatelet drugs
Boxed Warning: Xarelto increases the risk of serious bleeding and spinal hematomas in patients undergoing spinal puncture or anesthesia.
Not typically recommended during pregnancy unless the benefit clearly outweighs the risk. Always consult a healthcare provider if you are or may become pregnant.
May pass into breast milk; avoid breastfeeding unless advised by a physician.
Store at 68°F to 77°F (20°C to 25°C). Protect from moisture. Keep in the original container.
Avoid or Use With Caution:
Other anticoagulants (e.g., warfarin, heparin)
NSAIDs (e.g., ibuprofen, naproxen due to increased bleeding risk)
SSRIs/SNRIs (increased bleeding risk)
CYP3A4 and P-gp inhibitors/inducers (e.g., ketoconazole, rifampin, phenytoin)
Herbal products like St. John’s Wort
Always inform your provider about all medications, supplements, or herbal remedies.
Rivaroxaban (riv'' a rox' a ban) Xarelto® If you have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body, and possibly causing strokes) and are taking rivaroxaban to help prevent strokes or serious blood clots, you are at a higher risk of having a stroke after you stop taking this medication. Do not stop taking rivaroxaban without talking to your doctor. Continue to take rivaroxaban even if you feel well. Be sure to refill your prescription before you run out of medication so that you will not miss any doses of rivaroxaban. If you need to stop taking rivaroxaban, your doctor may prescribe another anticoagulant (''blood thinner'') to help prevent a blood clot from forming and causing you to have a stroke. If you have epidural or spinal anesthesia or a spinal puncture while taking a 'blood thinner' such as rivaroxaban, you are at risk of having a blood clot form in or around your spine that could cause you to become paralyzed. Tell your doctor if you have an epidural catheter that is left in your body or have or have ever had repeated epidural or spinal punctures, spinal deformity, or spinal surgery. Tell your doctor and pharmacist if you are taking anagrelide (Agrylin); aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others), indomethacin (Indocin, Tivorbex), ketoprofen, and naproxen (Aleve, Anaprox, others); cilostazol (Pletal); clopidogrel (Plavix); dipyridamole (Persantine); eptifibatide (Integrilin); heparin; prasugrel (Effient); ticagrelor (Brilinta); ticlopidine; tirofiban (Aggrastat), and warfarin (Coumadin, Jantoven). If you experience any of the following symptoms, call your doctor immediately: back pain, muscle weakness, numbness or tingling (especially in your legs), loss of control of your bowels or bladder, or inability to move your legs. Talk to your doctor about the risk of taking rivaroxaban. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with rivaroxaban and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/downloads/Drugs/DrugSafety/UCM280333.pdf) or the manufacturer's website to obtain the Medication Guide.
Rivaroxaban is used to treat deep vein thrombosis (DVT; a blood clot, usually in the leg) and pulmonary embolism (PE; a blood clot in the lung). Rivaroxaban may be continued to prevent DVT and/or PE from happening again after initial treatment is completed. It is also used to help prevent strokes or serious blood clots in people who have atrial fibrillation (a condition in which the heart beats irregularly, increasing the chance of clots forming in the body, and possibly causing strokes) without heart valve disease. Rivaroxaban may reduce the risk of DVT, which can lead to PE in people who are having hip replacement or knee replacement surgery. It is in a class of medications called factor Xa inhibitors. Rivaroxaban works by decreasing the clotting ability of the blood.
Rivaroxaban comes as a tablet to take by mouth. For the treatment of a DVT and PE, rivaroxaban is usually taken with food twice daily for 21 days, then once daily. When rivaroxaban is taken to prevent DVT and PE, it is usually taken once daily with food. When rivaroxaban is used to prevent a stroke in those with an irregular heartbeat, it is usually taken once daily with the evening meal. When rivaroxaban is taken to prevent DVT and PE after hip or knee replacement surgery it is usually taken with or without food once daily. The first dose should be taken at least 6 to 10 hours after surgery. Rivaroxaban is usually taken for 35 days after a hip replacement surgery and for 12 days after knee replacement surgery. Take rivaroxaban at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take rivaroxaban exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. If you are unable to swallow the tablets, you can crush them and mix with applesauce. Swallow the mixture right after you prepare it. Rivaroxaban can also be given in certain types of feeding tubes. Ask your doctor if you should take this medication in your feeding tube. Follow your doctor's directions carefully. Continue to take rivaroxaban even if you feel well. Do not stop taking rivaroxaban without talking to your doctor. If you stop taking rivaroxaban, your risk of a blood clot may increase.
Before taking rivaroxaban, tell your doctor and pharmacist if you are allergic to rivaroxaban, any other medications, or any of the ingredients in rivaroxaban tablets. Ask your pharmacist for a list of the ingredients. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: amiodarone (Cordarone, Pacerone), azithromycin (Zithromax), carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Tegretol-XR, Teril), clarithromycin (Biaxin, in Prevpac), conivaptan (Vaprisol), diltiazem (Cardizem, Dilacor, Tiazac), dronedarone (Multaq), erythromycin (E.E.S., E-Mycin, Erythrocin), felodipine (Plendil), fluconazole (Diflucan), indinavir (Crixivan), itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), lopinavir (in Kaletra), phenobarbital (Solfoton), phenytoin (Dilantin, Phenytek), quinidine, ranolazine (Ranexa), rifampin (Rifadin, in Rifamate, in Rifater, Rimactane), ritonavir (Norvir, in Kaletra), and verapamil (Calan, Covera, Isoptin, Verelan, in Tarka). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. tell your doctor what herbal products you are taking, especially St. John's wort. tell your doctor if you have heavy bleeding anywhere in your body that cannot be stopped. Your doctor will probably tell you not to take rivaroxaban. tell your doctor if you have had a valve in your heart replaced or have or have ever had problems with unusual bleeding, a bleeding disorder, or kidney or liver disease. tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking rivaroxaban, call your doctor. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking rivaroxaban.
Unless your doctor tells you otherwise, continue your normal diet.
If you take rivaroxaban once a day, take the missed dose as soon as you remember it on that day. Resume your regular dosing schedule the next day. If you take rivaroxaban twice a day, take the missed dose as soon as you remember it on that day. You may take 2 doses at the same time to make up for the missed dose. Resume your regular dosing schedule on the next day
Rivaroxaban may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: muscle spasm Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately: bloody, black, or tarry stools pink, or brown urine coughing up or vomiting blood or material that looks like coffee grounds frequent nosebleeds bleeding from your gums heavy menstrual bleeding weakness tiredness headache dizziness or fainting blurred vision pain in arm or leg rash itching difficulty breathing or swallowing hives pain or swelling at wound sites Rivaroxaban prevents blood from clotting normally so it may take longer than usual for you to stop bleeding if you are cut or injured. This medication may also cause you to bruise or bleed more easily. Call your doctor right away if bleeding or bruising is unusual. Rivaroxaban may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program. It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to rivaroxaban. Do not let anyone else take your medication. Your prescription is probably not refillable. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.