Tasigna (Nilotinib Hydrochloride Monohydrate)
Prescription required. May be split. Product of Canada. Shipped from Canada.
Prescription required. May be split. Product of Canada. Shipped from Canada.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Nilotinib Hydrochloride Monohydrate Information
(nye loe' ti nib)Nilotinib may cause QT prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death). Tell your doctor if you or anyone in your family has or has ever had long QT syndrome (an inherited condition in which a person is more likely to have QT prolongation) or you have or have ever had low levels of potassium or magnesium in your blood, an irregular heartbeat, or liver disease. Tell your doctor and pharmacist if you are taking amiodarone (Nexterone, Pacerone); antifungals such as ketoconazole, itraconazole (Onmel, Sporanox), or voriconazole (Vfend); chloroquine (Plaquenil); clarithromycin (Biaxin, in Prevpac); disopyramide (Norpace); erythromycin (E.E.S., Eryc, PCE); certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); haloperidol (Haldol); methadone (Dolophine, Methadose); moxifloxacin (Avelox); nefazodone; pimozide (Orap); procainamide; quinidine (in Nuedexta); sotalol (Betapace, Betapace AF, others); telithromycin (Ketek); and thioridazine. If you experience any of the following symptoms, stop taking nilotinib and call your doctor immediately: fast, pounding, or irregular heartbeat; fainting; loss of consciousness; or seizures. Do not eat any food for at least 2 hours before taking nilotinib and for 1 hour after taking this medication. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests, such as blood tests and electrocardiograms (EKGs, tests that record the electrical activity of the heart) before and during your treatment to be sure that it is safe for you to take nilotinib. Talk to your doctor about the risks of taking nilotinib.
Before taking nilotinib,
- tell your doctor and pharmacist if you are allergic to nilotinib, any other medications, or any of the ingredients in nilotinib capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: certain angiotensin-receptor blockers such as irbesartan (Avapro, in Avalide) and losartan (Cozaar, in Hyzaar); anticoagulants (''blood thinners'') such as warfarin (Coumadin, Jantoven); aripiprazole (Abilify); certain benzodiazepines such as alprazolam (Xanax), diazepam (Valium), midazolam, and triazolam (Halcion); buspirone (Buspar); certain calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Tiazac, others), felodipine, nicardipine (Cardene), nifedipine (Adalat, Procardia), nisoldipine (Sular), and verapamil (Calan, Verelan, others); certain cholesterol-lowering medications (statins) including atorvastatin (Lipitor), fluvastatin (Lescol XL), lovastatin (Altoprev), and simvastatin (Zocor); chlorpheniramine (Chlor-Trimeton, other cough and cold products); dexamethasone; dihydroergotamine (D.H.E. 45, Migranal); ergotamine (in Cafergot, in Ergomar); fentanyl (Actiq, Duragesic, Subsys); flecainide (Tambocor); certain medications for depression such as amitriptyline, desipramine (Norpramin); duloxetine (Cymbalta); imipramine (Tofranil); paroxetine (Brisdelle, Paxil, Pexeva); and venlafaxine (Effexor); certain oral medications for diabetes such as glipizide (Glucotrol) and tolbutamide; certain medications that suppress the immune system such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Prograf); certain medications for seizures such as carbamazepine (Equetro, Tegretol, Teril), phenobarbital, and phenytoin (Dilantin, Phenytek); mexiletine; certain nonsteroidal anti-inflammatory drugs (NSAIDs) such as celecoxib (Celebrex), diclofenac (Voltaren), ibuprofen (Advil, Motrin), naproxen (Aleve, Naprosyn), and piroxicam (Feldene); ondansetron (Zofran); propafenone (Rythmol); proton-pump inhibitors such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (AcipHex); quinine (Qualaquin); rifabutin (Mycobutin); rifampin (Rifadin); rifapentine (Priftin); risperidone (Risperdal); sildenafil (Viagra, Revatio); tamoxifen; testosterone (Androderm, Androgel, Striant, others); timolol; torsemide; tramadol (Ultram, in Ultracet); trazodone; and vincristine. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with nilotinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- if you are taking antacids containing magnesium, aluminum (Maalox, Mylanta, Tums, others), or simethicone, take the antacid 2 hours before or at least 2 hours after you take nilotinib.
- if you are taking a medication for indigestion, heartburn, or ulcers such as cimetidine (Tagamet), famotidine (Pepcid, in Duexis), nizatidine (Axid), or ranitidine (Zantac), take it at least 10 hours before or at least 2 hours after you take nilotinib.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you have had a stroke or surgery to remove the entire stomach (total gastrectomy). Also, tell your doctor if you have or have ever had decreased blood flow to your legs, any heart problems, bleeding problems, pancreatitis (swelling of the pancreas, a gland behind the that produces substances to help with digestion), or any condition that makes it difficult for you to digest lactose (milk sugar) or other sugars.
- tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are taking nilotinib. You should use effective birth control to prevent pregnancy during your treatment with nilotinib and for 14 days after your final dose. Talk to your doctor about birth control methods that you can use during your treatment. If you become pregnant while taking nilotinib, call your doctor immediately. Nilotinib may harm the fetus.
- tell your doctor if you are breast-feeding. You should not breast-feed while you are taking nilotinib and for 14 days after your final dose.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking nilotinib.
- loss of appetite
- difficulty falling asleep or staying asleep
- night sweats
- muscle cramps
- back, bone, joint, limb, or muscle pain
- hair loss
- dry or reddened skin
- numbness, burning, or tingling in the hands or feet
- unusual bleeding or bruising
- blood in urine
- bloody or black, tarry stools
- sudden headache, confusion, or changes in vision
- unusual tiredness or weakness
- chest pain or discomfort
- problems walking or speaking
- change in leg skin color
- pain or cold sensation in legs
- stomach pain with nausea and vomiting
- fever, chills, sore throat, ongoing cough and congestion, or other signs of infection
- pale skin
- shortness of breath
- weight gain
- swelling of hands, ankles, feet, or face
- pain or discomfort in the right upper stomach area
- yellowing of the skin and eyes
- dark urine
- urinating less often than usual