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(gra ni' se tron)
Before using granisetron injection,
- tell your doctor and pharmacist if you are allergic to granisetron, alosetron (Lotronex), dolasetron (Anzemet), ondansetron (Zofran, Zuplenz), palonosetron (Aloxi, in Akynzeo), any other medications, or any of the ingredients in granisetron injection. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Nexterone, Pacerone); azithromycin (Zithromax), chlorpromazine, citalopram (Celexa); clarithromycin (Biaxin, in Prevpac); erythromycin (E.E.S., ERYC, Erythrocin, others); fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Subsys); ketoconazole (Nizoral); lithium (Lithobid); medications for heart problems; medications to treat migraines such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex, in Treximet), and zolmitriptan (Zomig); mirtazapine (Remeron); monoamine oxidase (MAO) inhibitors including isocarboxazid (Marplan), methylene blue; linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); moxifloxacin (Avelox); pimozide (Orap); phenobarbital; selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax, others), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); serotonin–norepinephrine reuptake inhibitors (SNRI) medications desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), levomilnacipran (Fetzima), and venlafaxine; sotalol (Betapace, Sorine); thioridazine; and tramadol (Conzip, Ultram, in Ultracet). If you are receiving the extended-release injection, also tell your doctor if you are taking anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antiplatelet medications such as cilostazol, clopidogrel (Plavix), dipyridamole (Persantine, in Aggrenox), prasugrel (Effient), or ticlopidine. Your doctor may need to change the doses of your medications or monitor you more carefully for side effects. Many other medications may also interact with granisetron, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor if you have recently had stomach surgery or have constipation. Also, tell your doctor if you or anyone in your family has or has ever had long QT syndrome (condition that increases the risk of developing an irregular heartbeat that may cause fainting or sudden death), another type of irregular heartbeat or heart rhythm problem, electrolyte imbalance, or kidney or heart disease.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using granisetron injection, call your doctor.
- difficulty falling asleep or staying asleep
- difficulty breathing or swallowing
- shortness of breath
- swelling of the eyes, face, mouth, tongue, or throat
- chest pain
- injection site redness, swelling, or warmth with or without fever (for the extended-release injection)
- injection site bleeding, bruising, or pain (for the extended-release injection)
- stomach-area pain or swelling
- dizziness, lightheadedness, and fainting
- changes in heartbeat
- agitation, hallucinations (seeing things or hearing voices that do not exist). changes in mental status, or coma (loss of consciousness)
- tremors, loss of coordination, or stiff or twitching muscles
- excessive sweating
- nausea, vomiting, and diarrhea