(Upadacitinib)
Prescription required. Can not be split. Product of Australia. Shipped from Australia.
Prescription required. Can not be split. Product of Australia. Shipped from Australia.
Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor that suppresses immune system activity to reduce inflammation. It is prescribed for a range of chronic autoimmune inflammatory conditions, particularly in patients who have not responded to alternative biologic therapies (e.g., TNF blockers). Rinvoq is available as an oral extended-release tablet and as Rinvoq LQ, a liquid formulation for pediatric use. Doses are not interchangeable between forms, and changes should always be made with close monitoring by a healthcare provider.
Rheumatoid Arthritis (RA): For adults with moderate to severe RA unresponsive to TNF inhibitors.
Psoriatic Arthritis (PsA): For adults with inadequate response to TNF inhibitors.
Atopic Dermatitis (Eczema): For adults and children 12+ years with refractory moderate-to-severe eczema.
Ulcerative Colitis (UC): For adults with moderate-to-severe UC not responsive to other treatments.
Crohn’s Disease (CD): For adults with refractory moderate-to-severe CD.
Ankylosing Spondylitis & Non-radiographic Axial Spondyloarthritis: For adults with spine-related inflammatory conditions.
Giant Cell Arteritis: In combination with steroids or as monotherapy after tapering.
Polyarticular Juvenile Idiopathic Arthritis (JIA): For children aged 2+ unresponsive to TNF blockers.
Rinvoq should not be combined with other biologic DMARDs or other potent immunosuppressants.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Rinvoq is used to help manage chronic autoimmune and inflammatory diseases by:
Reducing inflammation and joint damage in arthritis
Improving skin symptoms in eczema
Controlling bowel inflammation in IBD (UC and Crohn’s)
Its oral formulation minimizes steroid dependence in vasculitis and arthritis
Rinvoq offers a helpful alternative to biologic injections, especially for long-term disease management.
Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Giant Cell Arthritis:
Adults: 15 mg once daily
Children: Weight-based for ages 2+, depending on condition
Atopic Dermatitis:
Adults <65: Start at 15 mg once daily; may increase to 30 mg if needed
Adults ≥65: 15 mg daily
Children ≥12 years: Weight-based
Ulcerative Colitis:
Induction: 45 mg daily for 8 weeks
Maintenance: 15–30 mg daily
Crohn’s Disease:
Induction: 45 mg daily for 12 weeks
Maintenance: 15–30 mg daily
Juvenile Idiopathic Arthritis:
Weight-based for ages 2+
Dosing recommendations may vary depending on individual needs. Take tablets whole with or without food. Do not crush or chew.
Take as soon as remembered unless it’s near the next dose. Never double up.
Call Poison Help (1-800-222-1222) in the US or 1-844-764-7669 in Canada, or seek emergency care.
The primary concern related to potent immunosuppressants like Rinvoq is an increased risk of infection.
Upper respiratory tract infection (e.g., cold, flu)
Acne
Herpes simplex
Headache
Nausea
Fatigue, muscle pain
Low red or white blood cell counts
Heart attack, stroke, blood clots
Serious infections (e.g., pneumonia, shingles, TB)
GI perforation (severe abdominal pain, fever)
Hepatitis, liver damage
New or changing skin lesions (potential cancer)
Kidney issues (e.g., low urination, blood in urine)
Mental status changes, neurologic events
You are allergic to upadacitinib
You are using another JAK inhibitor, biologic DMARD (e.g., Humira, Enbrel), or strong immunosuppressant (e.g., azathioprine)
Active/chronic infection
Liver disease or hepatitis
Cardiovascular risk (stroke, heart attack history)
GI disorders (e.g., diverticulitis)
Cancer history or immunosuppression
Are pregnant or breastfeeding
Boxed Warnings: Serious infections, cancer risk, blood clots, cardiovascular events, and mortality.
Before starting, it’s important to coordinate with your healthcare provider to ensure you have received all recommended vaccinations. A tuberculosis skin test and blood tests are also recommended to monitor baseline blood cell counts and liver function.
May cause harm to unborn babies. Use birth control during and for 4 weeks after treatment.
Do not breastfeed during treatment or within 6 days of the last dose.
Enroll in the pregnancy surveillance program if exposed.
Rinvoq Tablets: Store between 36°F and 77°F (2°C to 25°C) in the original container.
Rinvoq LQ (Liquid): Store between 36°F and 86°F (2°C to 30°C). Discard 60 days after opening.
Avoid:
Live vaccines (MMR, varicella, etc.)
Grapefruit and grapefruit juice
Concurrent use with:
Other immunosuppressants (e.g., azathioprine, cyclosporine)
Certain antibiotics (e.g., clarithromycin, rifampin)
Antifungals (e.g., ketoconazole)
NSAIDs and corticosteroids (increased risk of GI perforation)
Always tell your doctor about all medications and supplements you’re taking.
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.