Before taking glyburide and metformin,
tell your doctor and pharmacist if you are allergic to glyburide, metformin, any of the ingredients in glyburide and metformin tablets, or any other medications. Ask your pharmacist for a list of the ingredients.
tell your doctor if you are taking bosentan (Tracleer). Your doctor may tell you not to take glyburide if you are taking this medication.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiloride (Midamor); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril , enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) or naproxen (Aleve, Naprosyn); beta-blockers such as atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, InnoPran); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Diltzac, others), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), or verapamil (Calan, Covera, Verelan, in Tarka); chloramphenicol; cimetidine (Tagamet); clarithromycin (Biaxin, in Prevpac); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); disopyramide (Norpace); diuretics ('water pills'); fluconazole (Diflucan); fluoxetine (Prozac, Sarafem, Selfemra); furosemide (Lasix); hormone replacement therapy; insulin or other medications for diabetes; isoniazid (Laniazid, in Rifamate, in Rifater); MAO inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); medications for allergies, asthma, and colds; medications for mental illness and nausea; miconazole (Lotrimin, Monistat, others); morphine (MS Contin, others); niacin; oral contraceptives (birth control pills); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); phenytoin (Dilantin, Phenytek); probenecid (Benemid, in Colbenemid); procainamide; quinidine (in Nuedexta); quinine; quinolone and fluoroquinolone antibiotics such as cinoxacin (no longer available in the U.S., Cinobac), ciprofloxacin (Cipro), enoxacin (no longer available in the U.S., Penetrex), gatifloxacin, levofloxacin (Levaquin), lomefloxacin (no longer available in the U.S., Maxaquin), moxifloxacin (Avelox), nalidixic acid (no longer available in the U.S., NegGram), norfloxacin (no longer available in the U.S., Noroxin), ofloxacin (no longer available in the U.S., Floxin), sparfloxacin (no longer available in the U.S., Zagam), trovafloxacin and alatrofloxacin combination (no longer available in the U.S., Trovan); ranitidine (Zantac); rifampin; salicylate pain relievers such as choline magnesium trisalicylate, choline salicylate (Arthropan), diflunisal, magnesium salicylate (Doan's, others), or salsalate (Argesic, Disalcid, Salgesic); sulfa antibiotics such as cotrimoxazole (Bactrim, Septra); sulfasalazine (Azulfidine); thyroid medications; triamterene (Dyrenium, in Maxzide, others); trimethoprim (Primsol, in Bactrim, in Septra); or vancomycin (Vancocin, others).
in addition to the conditions listed in the IMPORTANT WARNING section, tell your doctor if you or any of your family members have or have ever had G6PD deficiency (an inherited condition causing premature destruction of red blood cells or hemolytic anemia); also tell your doctor if you have or have ever had hormone disorders involving the adrenal, pituitary, or thyroid gland; or acute or chronic metabolic acidosis.
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking glyburide and metformin, call your doctor.
plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Glyburide and metformin may make your skin sensitive to sunlight.
tell your doctor if you eat less or exercise more than usual. This can affect your blood sugar. Your doctor will give you instructions if this happens.