Glucovance (Glyburide / Metformin Hydrochloride)
Glucovance
1.25mg/250mg Tablet
Prescription required. Can not be split. Product of Australia. Shipped from Australia.
Glucovance
2.5mg/500mg Tablet
Prescription required. Can not be split. Product of Australia. Shipped from Australia.
Glucovance
5mg/500mg Tablet
Prescription required. Can not be split. Product of Australia. Shipped from Australia.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Glyburide / Metformin Hydrochloride Information
(glye' byoor ide) (met for' min)
Metformin may rarely cause a serious, life-threatening condition called lactic acidosis. Tell your doctor if you have kidney disease. Your doctor will probably tell you not to take glyburide and metformin. Also, tell your doctor if you are over 65 years old and if you have ever had a heart attack; stroke; diabetic ketoacidosis (blood sugar that is high enough to cause severe symptoms and requires emergency treatment); a coma; or heart or liver disease. Tell your doctor if you are taking acetazolamide (Diamox), dichlorphenamide (Keveyis), methazolamide, topiramate (Topamax, in Qsymia), or zonisamide (Zonegran). Tell your doctor if you have recently had any of the following conditions, or if you develop them during treatment: serious infection; severe diarrhea, vomiting, or fever; or if you drink much less fluid than usual for any reason. You may have to stop taking glyburide and metformin until you recover. If you are having surgery, including dental surgery, or any major medical procedure, tell the doctor that you are taking glyburide and metformin. Also, tell your doctor if you plan to have any x-ray procedure in which dye is injected, especially if you drink or have ever drunk large amounts of alcohol or have or have had liver disease or heart failure. You may need to stop taking glyburide and metformin before the procedure and wait 48 hours to restart treatment. Your doctor will tell you exactly when you should stop taking glyburide and metformin and when you should start taking it again. If you experience any of the following symptoms, stop taking glyburide and metformin and call your doctor immediately: extreme tiredness, weakness, or discomfort; nausea; vomiting; stomach pain; decreased appetite; deep and rapid breathing or shortness of breath; dizziness; lightheadedness; fast or slow heartbeat; flushing of the skin; muscle pain; or feeling cold in your hands or feet. Tell your doctor if you regularly drink alcohol or sometimes drink large amounts of alcohol in a short time (binge drinking). Drinking alcohol increases your risk of developing lactic acidosis or may cause a decrease in blood sugar. Consuming alcohol while taking glyburide and metformin also rarely may cause symptoms such as flushing (reddening of the face), headache, nausea, vomiting, chest pain, weakness, blurred vision, mental confusion, sweating, choking, breathing difficulty, and anxiety. Ask your doctor how much alcohol is safe to drink while you are taking glyburide and metformin. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before and during treatment to check how well your kidneys are working and your body's response to glyburide and metformin. Talk to your doctor about the risks of taking glyburide and metformin.-
Before taking glyburide and metformin,
- tell your doctor and pharmacist if you are allergic to glyburide, metformin, any of the ingredients in glyburide and metformin tablets, or any other medications. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you are taking bosentan (Tracleer). Your doctor may tell you not to take glyburide if you are taking this medication.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiloride (Midamor); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril , enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), and trandolapril (Mavik); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin) or naproxen (Aleve, Naprosyn); beta-blockers such as atenolol (Tenormin), labetalol (Trandate), metoprolol (Lopressor, Toprol XL), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, InnoPran); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Cartia, Diltzac, others), felodipine, isradipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab CR, Procardia), or verapamil (Calan, Covera, Verelan, in Tarka); chloramphenicol; cimetidine (Tagamet); clarithromycin (Biaxin, in Prevpac); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); disopyramide (Norpace); diuretics ('water pills'); fluconazole (Diflucan); fluoxetine (Prozac, Sarafem, Selfemra); furosemide (Lasix); hormone replacement therapy; insulin or other medications for diabetes; isoniazid (Laniazid, in Rifamate, in Rifater); MAO inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); medications for allergies, asthma, and colds; medications for mental illness and nausea; miconazole (Lotrimin, Monistat, others); morphine (MS Contin, others); niacin; oral contraceptives (birth control pills); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); phenytoin (Dilantin, Phenytek); probenecid (Benemid, in Colbenemid); procainamide; quinidine (in Nuedexta); quinine; quinolone and fluoroquinolone antibiotics such as cinoxacin (no longer available in the U.S., Cinobac), ciprofloxacin (Cipro), enoxacin (no longer available in the U.S., Penetrex), gatifloxacin, levofloxacin (Levaquin), lomefloxacin (no longer available in the U.S., Maxaquin), moxifloxacin (Avelox), nalidixic acid (no longer available in the U.S., NegGram), norfloxacin (no longer available in the U.S., Noroxin), ofloxacin (no longer available in the U.S., Floxin), sparfloxacin (no longer available in the U.S., Zagam), trovafloxacin and alatrofloxacin combination (no longer available in the U.S., Trovan); ranitidine (Zantac); rifampin; salicylate pain relievers such as choline magnesium trisalicylate, choline salicylate (Arthropan), diflunisal, magnesium salicylate (Doan's, others), or salsalate (Argesic, Disalcid, Salgesic); sulfa antibiotics such as cotrimoxazole (Bactrim, Septra); sulfasalazine (Azulfidine); thyroid medications; triamterene (Dyrenium, in Maxzide, others); trimethoprim (Primsol, in Bactrim, in Septra); or vancomycin (Vancocin, others).
- in addition to the conditions listed in the IMPORTANT WARNING section, tell your doctor if you or any of your family members have or have ever had G6PD deficiency (an inherited condition causing premature destruction of red blood cells or hemolytic anemia); also tell your doctor if you have or have ever had hormone disorders involving the adrenal, pituitary, or thyroid gland; or acute or chronic metabolic acidosis.
- tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking glyburide and metformin, call your doctor.
- plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Glyburide and metformin may make your skin sensitive to sunlight.
- tell your doctor if you eat less or exercise more than usual. This can affect your blood sugar. Your doctor will give you instructions if this happens.
- stomach pain
- nausea or vomiting
- diarrhea
- dizziness
- chest pain
- rash
- yellowing of the skin or eyes
- light-colored stools
- dark urine
- pain in the right upper part of the stomach
- unusual bleeding or bruising
- fever
- sore throat
- swelling of the eyes, face, lips, tongue, or throat
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.