Changes coming to U.S. import regulations, effective August 29th, 2025. All shipments may be affected. Read more for continued updates.
(Rivaroxaban)
Prescription required. Can not be split. Product of Germany. Shipped from Australia.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom.
Prescription required. Can not be split. Product of Germany. Shipped from Australia.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom.
Prescription required. Can not be split. Product of New Zealand. Shipped from New Zealand.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom. Xarelto is also marketed internationally under the name Xarelto Treatment Initiation Pack.
Prescription required. Can not be split. Product of New Zealand. Shipped from New Zealand.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom.
Xarelto (rivaroxaban) is a direct oral anticoagulant (DOAC) that works by inhibiting Factor Xa, an enzyme crucial for blood clot formation. It is widely prescribed to reduce the risk of stroke, deep vein thrombosis (DVT), pulmonary embolism (PE), and other clot-related conditions. Xarelto is an oral, once-daily blood thinner that often requires less frequent monitoring when compared with alternatives like warfarin.
Atrial Fibrillation (non-valvular): To reduce the risk of stroke and systemic embolism (blood clot formation).
Deep Vein Thrombosis (DVT): Treatment and prevention of recurrent blood clots in areas of the body like the legs.
Pulmonary Embolism (PE): Treatment and long-term prevention of blood clots that travel to and damage the lungs.
Post-Surgical DVT Prevention: After hip or knee replacement surgery.
Coronary Artery Disease (CAD) or Peripheral Artery Disease (PAD): To reduce cardiovascular risk, often in combination with aspirin.
Venous Thromboembolism (VTE) in Children: For pediatric patients aged 2+ (weight-based dosing).
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Xarelto helps prevent and treat blood clots by:
Blocking the activity of Factor Xa, interrupting the clotting cascade.
Reducing the risk of stroke in atrial fibrillation patients.
Offering convenience over routine INR checks required for warfarin.
Supporting recovery after orthopedic surgery or cardiovascular procedures.
Atrial Fibrillation: 20 mg once daily with evening meal (15 mg for reduced kidney function).
DVT/PE Treatment: 15 mg twice daily for 21 days, then 20 mg once daily.
Coronary Artery Disease/Peripheral Artery Disease: 2.5 mg twice daily with aspirin (81 mg) once daily.
Post-Surgical Prevention of blood clots: 10 mg once daily.
Pediatric Use (VTE): Weight-based; tablet or liquid formulation available.
Take tablets with food (particularly important for pediatric patients, as it increases the reliability of absorption). Swallow whole; do not split or crush unless instructed.
Managing a missed dose is different depending on your current stage of treatment. For treatment of an existing clot (often dosed twice daily), taking both tablets at once may be recommended to ensure you receive the full daily dose. For long-term prevention of clots, doses should not be doubled up. In general, your provider may recommend:
For once-daily doses: Take as soon as remembered; skip if close to the next dose.
For twice-daily doses: Take both tablets in one dose if a dose is missed.
Always consult your healthcare providers for personalized advice, as missing a dose or doubling up on a dose may cause significant risks.
Seek emergency medical care or contact Poison Help at 1-800-222-1222 in the US or 1-844-764-7669 in Canada.
The primary concern when taking blood thinners like Xarelto is an increased risk of bleeding. In some instances, bleeding may be serious or life-threatening. Always discuss ways to manage your risks with your healthcare providers to help promote safety.
Bleeding (nosebleeds, gum bleeding, bruising)
Abdominal pain
Fatigue
Muscle spasms
Back pain
Dizziness
Mood changes
Severe or prolonged bleeding
Blood in urine or stool (may sometimes appear dark or tarry if the blood has already clotted while traveling through the digestive tract—common in upper GI bleeds like stomach ulcers)
Coughing up blood
Sudden severe headaches (possible brain bleed)
Vision changes, weakness, or numbness
Spinal or epidural hematoma (especially with spinal procedures)
Do NOT take Xarelto if:
You are actively bleeding or have a bleeding disorder
You are allergic to rivaroxaban or other inactive ingredients
You have severe liver disease with associated clotting risk
Use With Caution If You Have:
Kidney or liver impairment
History of gastrointestinal ulcers or recent bleeding
Upcoming spinal procedures or use of spinal/epidural catheters
Combined use with other anticoagulants or antiplatelet drugs
Boxed Warning: Xarelto increases the risk of serious bleeding and spinal hematomas in patients undergoing spinal puncture or anesthesia.
Not typically recommended during pregnancy unless the benefit clearly outweighs the risk. Always consult a healthcare provider if you are or may become pregnant.
May pass into breast milk; avoid breastfeeding unless advised by a physician.
Store at 68°F to 77°F (20°C to 25°C). Protect from moisture. Keep in the original container.
Avoid or Use With Caution:
Other anticoagulants (e.g., warfarin, heparin)
NSAIDs (e.g., ibuprofen, naproxen due to increased bleeding risk)
SSRIs/SNRIs (increased bleeding risk)
CYP3A4 and P-gp inhibitors/inducers (e.g., ketoconazole, rifampin, phenytoin)
Herbal products like St. John’s Wort
Always inform your provider about all medications, supplements, or herbal remedies.
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.