Vosevi (Sofosbuvir / Velpatasvir / Voxilaprevir)

400mg/100mg/100mg Tablet

Prescription required. Can not be split. Product of Australia. Shipped from Australia.

To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more

Sofosbuvir / Velpatasvir / Voxilaprevir Information

Sofosbuvir, Velpatasvir, and Voxilaprevir (soe fos' bue vir) (vel pat' as vir) (vox" i la' pre vir) Vosevi® You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage), but not have any symptoms of the disease. In this case, taking the combination of sofosbuvir, velpatasvir, and voxilaprevir may increase the risk that your infection will become more serious or life-threatening and you will develop symptoms. Tell your doctor if you have or ever had a hepatitis B virus infection. Your doctor will order a blood test to see if you have or have ever had hepatitis B infection. Your doctor will also monitor you for signs of hepatitis B infection during and for several months after your treatment. If necessary, your doctor may give you medication to treat this infection before and during your treatment with the combination of sofosbuvir, velpatasvir, and voxilaprevir. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea or vomiting, pale stools, stomach pain, or dark urine. Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before, during, and after your treatment to check your body's response to the combination of sofosbuvir, velpatasvir, and voxilaprevir. Talk to your doctor about the risk(s) of taking sofosbuvir, velpatasvir, and voxilaprevir.

The combination of sofosbuvir, velpatasvir, and voxilaprevir is used to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus) in adults who have already received other HCV treatments. Sofosbuvir is a non-nucleoside NS5B polymerase inhibitor. It works by decreasing the amount of hepatitis C virus in the body. Velpatasvir is a hepatitis C virus (HCV) NS5A inhibitor. It works by stopping the virus that causes hepatitis C from spreading inside the body. Voxilaprevir is in a class of medications called HCV NS3/4A protease inhibitors. It works by decreasing the amount of HCV in the body.

The combination of sofosbuvir, velpatasvir, and voxilaprevir comes as a tablet to take by mouth. It is usually taken with food once daily for 12 weeks. Take sofosbuvir, velpatasvir, and voxilaprevir at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sofosbuvir, velpatasvir, and voxilaprevir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. Continue to take sofosbuvir, velpatasvir, and voxilaprevir even if you feel well. The length of your treatment depends on your condition, how well you respond to the medication, and whether you experience severe side effects. Do not stop taking sofosbuvir, velpatasvir, and voxilaprevir without talking to your doctor. Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Before taking sofosbuvir, velpatasvir, and voxilaprevir, tell your doctor and pharmacist if you are allergic to sofosbuvir, velpatasvir, and voxilaprevir, any other medications, or any of the ingredients in the combination of sofosbuvir, velpatasvir, and voxilaprevir tablets. Ask your pharmacist for a list of the ingredients. tell your doctor if you are taking rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor will probably tell you not to take sofosbuvir, velpatasvir, and voxilaprevir if you are taking rifampin. tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone); cholesterol-lowering medications (statins) such as atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), lovastatin (Altoprev), pitavastatin (Livalo), pravastatin (Pravachol), rosuvastatin (Crestor), simvastatin (Flolipid, Zocor, in Vytorin); cyclosporine (Gengraf, Neoral, Sandimmune); dabigatran (Pradaxa); digoxin (Lanoxin); H2 blockers such as cimetidine (Tagamet), famotidine (Pepcid), nizatidine (Axid), and ranitidine (Zantac); certain medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) including atazanavir (Reyataz), efavirenz (Sustiva, in Atripla), lopinavir (in Kaletra), tenofovir (Viread, in Atripla, Complera, Stribild, Truvada, others), and tipranavir (Aptivus) when taken with ritonavir (Norvir); imatinib (Gleevec); irinotecan (Camptosar); lapatinib (Tykerb); methotrexate (Otrexup, Rasuvo, Xatmep); mitoxantrone; rifabutin (Mycobutin); rifapentine (Priftin); certain medications for seizures such as carbamazepine (Carbatrol, Epitol, Equetro, Tegretol), oxcarbazepine (Trileptal), phenobarbital, or phenytoin (Dilantin, Phenytek); sulfasalazine (Azulfidine); topotecan (Hycamtin); and warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with sofosbuvir and velpatasvir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. if you are taking aluminum or magnesium containing antacids (Maalox, Mylanta), take them 4 hours before or 4 hours after sofosbuvir, velpatasvir, and voxilaprevir. tell your doctor what herbal products you are taking, especially St. John's wort. tell your doctor if you have or have ever had any type of liver disease other than hepatitis C or kidney disease or if you are currently on dialysis. tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking sofosbuvir, velpatasvir, and voxilaprevir, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose with food as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

Sofosbuvir, velpatasvir, and voxilaprevir may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: headache fatigue diarrhea weakness difficulty falling asleep or staying asleep depression Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately: rash Sofosbuvir, velpatasvir, and voxilaprevir may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.