Before taking sofosbuvir and velpatasvir,
tell your doctor and pharmacist if you are allergic to sofosbuvir, velpatasvir, any other medications, or any of the ingredients in sofosbuvir and velpatasvir tablets. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Nexterone, Pacerone); atorvastatin (Lipitor, in Caduet); carbamazepine (Carbatrol, Epitol, Equetro, Tegretol, Teril); digoxin (Lanoxin); efavirenz (Sustiva, in Atripla); oxcarbazepine (Oxtellar, Trileptal); phenobarbital; phenytoin (Dilantin, Phenytek); proton-pump inhibitors such as dexlansoprazole (Dexilant), esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid, in Prevpac), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), and rabeprazole (AcipHex): rifabutin (Mycobutin); rifampin (Rifadin, Rimactane, in Rifamate, Rifater); rifapentine (Priftin); rosuvastatin (Crestor); tenofovir DF (Viread, in Atripla, Complera, Stribild, Truvada, others); tipranavir (Aptivus) when taken with ritonavir (Norvir); topotecan (Hycamtin); and warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with sofosbuvir and velpatasvir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
if you are taking antacids, take them 4 hours before or 4 hours after sofosbuvir and velpatasvir.
tell your doctor if you are taking a medication for indigestion, heartburn, or ulcers (H2 blockers) such as cimetidine, ranitidine (Zantac), famotidine (Pepcid, in Duexis), or nizatidine. Your doctor may tell you to take this medication 12 hours before or 12 hours after sofosbuvir and velpatasvir, or at the same time that you take sofosbuvir and velpatasvir.
tell your doctor what herbal products you are taking, especially St. John's wort.
tell your doctor if you have human immunodeficiency virus (HIV), or have or have ever had any type of liver problem other than hepatitis C or kidney disease or are on dialysis.
tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking sofosbuvir and velpatasvir, call your doctor.