Before taking brexpiprazole,
tell your doctor and pharmacist if you are allergic to brexpiprazole, any other medications, or any of the ingredients in brexpiprazole tablets. Ask your pharmacist for a list of the ingredients.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: antidepressants such as duloxetine (Cymbalta), fluoxetine ( Prozac, Sarafem, Symbyax), and paroxetine (Brisdelle, Paxil); certain antifungal medications such as fluconazole (Diflucan), itraconazole (Onmel, Sporanox), and ketoconazole (Extina, Nizoral, Xolegel); clarithromycin (Biaxin, in Prevpac); medications to control high blood pressure; quinidine (in Nuedexta); and rifampin (Rifadin, Rimactane, in Rifamate, Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with brexpiprazole, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
tell your doctor what herbal products you are taking, especially St. John's wort.
tell your doctor or if you or anyone in your family has or has ever had diabetes. Tell you doctor if you have or have ever had a stroke, a ministroke (TIA), chest pain, heart disease, a heart attack, an irregular heartbeat, heart failure, trouble keeping your balance, any condition that makes it difficult for you to swallow, high or low blood pressure, seizures, a high level of fats (cholesterol and triglycerides) in your blood, a low number of white blood cells, or kidney or liver disease. Also tell your doctor if you have severe vomiting or diarrhea or signs of dehydration now, or if you develop these symptoms at any time during your treatment.
tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, or if you plan to become pregnant or are breastfeeding. If you become pregnant while taking brexpiprazole, call your doctor. Brexpiprazole may cause problems in newborns following delivery if it is taken during the last months of pregnancy.
you should know that brexpiprazole may make you drowsy. Do not drive a car or operate hazardous machinery until you know how this medication affects you.
you should know that you may experience hyperglycemia (increases in your blood sugar) while you are taking this medication, even if you do not already have diabetes. If you have schizophrenia, you are more likely to develop diabetes than people who do not have schizophrenia, and taking brexpiprazole or similar medications may increase this risk. Tell your doctor immediately if you have any of the following symptoms while you are taking brexpiprazole: extreme thirst, frequent urination, extreme hunger, blurred vision, or weakness. It is very important to call your doctor as soon as you have any of these symptoms, because high blood sugar can cause a serious condition called ketoacidosis. Ketoacidosis may become life-threatening if it is not treated at an early stage. Symptoms of ketoacidosis include dry mouth, nausea and vomiting, shortness of breath, breath that smells fruity, and decreased consciousness.
you should know that brexpiprazole may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking brexpiprazole. To help avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
you should know that brexpiprazole may make it harder for your body to cool down when it gets very hot. Tell your doctor if you plan to exercise or be exposed to extreme heat.
you should know that brexpiprazole may cause an increase in weight. It is important to have your weight checked periodically while you are taking this medication.