Before taking darunavir, cobicistat, emtricitabine, and tenofovir,
tell your doctor and pharmacist if you are allergic to darunavir, cobicistat, emtricitabine, and tenofovir, any other medications, sulfa medications, or any of the other ingredients in darunavir, cobicistat, emtricitabine, and tenofovir tablets. Ask your pharmacist for a list of the ingredients.
tell your doctor if you are taking any of the following medications: alfuzosin (Uroxatral); carbamazepine (Carbatrol, Epitol, Tegretol, others); cisapride (Propulsid) (not available in the U.S.); colchicine (Colcyrs, Mitigare) in people with kidney or liver disease; dronedarone (Multaq); elbasvir and grazoprevir (Zepatier); ergot medications such as dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), and methylergonovine (Methergine); ivabradine (Corlanor); lomitapide (Juxtapid); lovastatin (Altoprev); lurasidone (Latuda); midazolam by mouth; naloxegol (Movantik); phenobarbital; phenytoin (Dilantin, Phenytek); pimozide (Orap); ranolazine (Ranexa); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); St. John's wort; sildenafil (only Revatio, brand used for lung disease); simvastatin (Simcor, Zocor, in Vytorin); or triazolam (Halcion). Your doctor will probably tell you not to take darunavir, cobicistat, emtricitabine, and tenofovir if you are taking one or more of these medications.
tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglycoside antibiotics such as gentamicin; antifungal medications such as isavuconazonium (Cresemba), itraconazole (Onmel, Sporanox), ketoconazole, and voriconazole (Vfend); antiviral medications such as acyclovir (Sitavig, Zovirax), cidofovir, ganciclovir (Cytovene, Valcyte), valacyclovir (Valtrex), and valganciclovir (Valcyte); antibiotics such as clarithromycin (Biaxin, in PrevPac), erythromycin (E.E.S, Eryc, Ery-Tab), and telithromycin (no longer available in U.S., Ketek); apixaban (Eliquis); artemether and lumefantrine (Coartem); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); benzodiazepines such as clonazepam (Klonopin), diazepam (Diastat, Valium), estazolam, flurazepam, midazolam given intravenously (into a vein), and zolpidem (Ambien, Zolpmist); beta blockers such as arvedilol (Coreg), metoprolol (Lopressor, Toprol-XL, in Dutoprol), and timolol; bosentan (Tracleer); buprenorphine (Belbuca, Buprenex, others); buprenorphine and naloxone (Bunavail, Suboxone); buspirone; calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Diltzac, Tiazac, others), felodipine, nifedipine (Adalat CC, Afeditab CR, Procardia), and verapamil (Calan, Verelan, in Tarka); carvedilol (Coreg); cholesterol-lowering medications (statins) such as atorvastatin (Lipitor, in Caduet), fluvastatin (Lescol), pitavastatin (Livalo), pravastatin (Pravachol), and rosuvastatin (Crestor); dasatinib (Sprycel); medications for depression such as amitriptyline, desipramine (Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), paroxetine (Brisdelle, Paxil, Pexeva), sertraline (Zoloft), and trazodone; digoxin (Lanoxin); eslicarbazepine (Aptiom); everolimus (Afinitor, Zortress); fentanyl (Duragesic, Subsys); fesoterodine (Toviaz); irinotecan (Camptosar); medications for irregular heartbeat such as amiodarone (Nexterone, Pacerone), disopyramide (Norpace), flecainide, lidocaine (Xylocaine), mexiletine, propafenone (Rythmol), and quinidine (in Nuedexta); medications that suppress the immune system such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), and tacrolimus (Prograf); methadone (Methadose); nilotinib (Tasigna); oral contraceptives ('birth control pills'); oxcarbazepine (Trileptal); oxycodone (Xtampza, in Percodan); perphenazine; quetiapine (Seroquel); phosphodiesterase (PDE5) inhibitors such as avanafil (Stendra), avanafil (Stendra);sildenafil (Viagra), tadalafil (Adcirca, Cialis), and vardenafil (Levitra, Staxyn); rifabutin (Mycobutin); rifapentine (Priftin); risperidone (Risperdal); rivaroxaban (Xarelto); salmeterol (Serevent, in Advair); simeprevir (Olysio; no longer available in US); solifenacin (Vesicare); oral or inhaled steroids such as betamethasone, budesonide (Pulmicort), ciclesonide (Alvesco, Omnaris, Zetonna) dexamethasone, fluticasone (Flonase, Flovent, in Advair), methylprednisolone, mometasone (Asmanex, in Dulera), and triamcinolone; thioridazine; ticagrelor (Brilinta); tramadol (Conzip, Ultram); vinblastine; vincristine; and warfarin (Coumadin, Jantoven). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with darunavir, cobicistat, emtricitabine, and tenofovir, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
tell your doctor if you have or have ever had the conditions mentioned in the IMPORTANT WARNING section, any type of infection that does not go away or that comes and goes such as tuberculosis (TB; a type of lung infection) or cytomegalovirus (CMV; a viral infection that may cause symptoms in patients with weak immune systems); diabetes; hemophilia (a disease in which the blood does not clot normally); or liver or kidney disease.
tell your doctor if you are pregnant or plan to become pregnant. If you become pregnant while taking darunavir, cobicistat, emtricitabine, and tenofovir, call your doctor.
tell your doctor if you are breastfeeding. You should not breastfeed if you are infected with HIV or if you are taking darunavir, cobicistat, emtricitabine, and tenofovir.
you should be aware that your body fat may increase or move to different areas of your body, such as your upper back, neck (''buffalo hump''), breasts, and around your stomach. You may notice a loss of body fat from your face, legs, and arms.
you should know that while you are taking medications to treat HIV infection, your immune system may get stronger and begin to fight other infections that were already in your body. This may cause you to develop symptoms of those infections. If you have new or worsening symptoms during your treatment with darunavir, cobicistat, emtricitabine, and tenofovir, be sure to tell your doctor.