Changes coming to U.S. import regulations, effective August 29th, 2025. All shipments may be affected. Read more for continued updates.
(Rifaximin)
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom. Xifaxan is also marketed internationally under the name Xifaxanta.
Prescription required. Can not be split. Product of Italy. Shipped from Australia.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom.
Xifaxan is a non-absorbed antibiotic that works locally in the intestines to manage bacterial growth and treat infections without entering the bloodstream. It is commonly prescribed for:
Traveler’s diarrhea caused by Escherichia coli (E. coli)
Irritable bowel syndrome with diarrhea (IBS-D)
Hepatic encephalopathy in adults with liver disease to reduce the risk of recurrent brain function decline
Because Xifaxan remains confined to the gut, it is highly targeted and does not treat systemic infections.
Traveler’s Diarrhea: Treats non-invasive E. coli-induced diarrhea in adults and children age 12 and older.
IBS-D (Irritable Bowel Syndrome with Diarrhea): FDA-approved for short-term treatment in adults.
Hepatic Encephalopathy: Reduces the recurrence risk of overt hepatic encephalopathy in adults with advanced liver disease.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Xifaxan is prescribed for gastrointestinal and liver-related conditions where bacterial toxins or overgrowth contribute to symptoms. It helps to:
Eliminate harmful intestinal bacteria
Improve cognitive symptoms in liver disease
Reduce diarrhea in IBS and travel-related infections
Because it’s poorly absorbed, Xifaxan minimizes systemic side effects, making it an effective option for patients needing localized gut treatment.
General dosage recommendations:
Traveler’s Diarrhea: 200 mg 3× daily for 3 days
IBS-D: 550 mg 3× daily for 14 days (can repeat up to 2 more times if symptoms recur)
Hepatic Encephalopathy: 550 mg 2× daily, often with lactulose
Can be taken with or without food
Follow the full prescribed duration even if symptoms improve early
Individual recommendations may vary based on need. Always consult your healthcare provider if you have questions about your dose.
Take as soon as remembered unless close to the next dose. Do not double up.
Symptoms are unlikely due to low systemic absorption. Call 1-800-222-1222 in the US or 1-844-764-7669 in Canada, or seek emergency care.
Many symptoms reported by patients using Xifaxan can also be attributed to the conditions being managed. If any symptoms persist or worsen during treatment, contact your healthcare provider.
Nausea
Dizziness
Swelling of hands or feet
Fatigue
Abnormal liver tests
Anemia
Skin rash
Allergic reaction (rash, swelling, difficulty breathing)
Bloody or watery diarrhea (may indicate Clostridium difficile or another infection)
Severe stomach pain or bloating
Sudden fluid retention around the abdomen (in liver disease patients)
Are allergic to rifaximin or other rifamycin antibiotics (e.g., rifampin, rifapentine)
Have diarrhea with blood in stool
Severe liver disease
Recurring diarrhea not caused by E. coli
Limited data available. Discuss risks and benefits with your provider if pregnant or nursing.
Store at room temperature (68–77°F / 20–25°C)
Keep away from moisture and heat
Store in the original bottle with the lid closed
Keep out of reach of children and pets
Avoid anti-diarrheal medications if experiencing bloody or watery stools
Xifaxan has minimal drug interactions due to low absorption, but always disclose all medications to your provider
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.