Before taking crizotinib,
tell your doctor and pharmacist if you are allergic to crizotinib, any other medications, or any of the ingredients in crizotinib capsules. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.
tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: amiodarone (Cordarone, Pacerone); certain antibiotics such as clarithromycin (Biaxin); certain antifungal medications such as itraconaozole (Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend); chloroquine (Aralen); chlorpromazine (Thorazine); citalopram (Celexa); cyclosporine (Gengraf, Neoral, Sandimmune); dihydroergotamine (D.H.E. 45, Migranal); disopyramide (Norpace); dofetilide (Tikosyn); droperidol (Inapsine); ergotamine (Ergomar, in Cafergot, in Migergot); erythromycin (E.E.S., Erythrocin); fentanyl (Abstral, Actiq, Fentora, Lazanda, Onsolis); flecainide (Tambocor); certain medications for human immunodeficiency virus (HIV) such as atazanavir (Reyataz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), and saquinavir (Invirase); certain medications for seizures such as carbamazepine (Carbatrol, Equetro, Tegretol), phenobarbital, and phenytoin (Dilantin); mesoridazine (Serentil); methadone (Dolophine); moxifloxacin (Avelox); nefazodone; pentamidine (NebuPent, Pentam); pimozide (Orap); procainamide (Pronestyl); quinidine (in Nuedexta); rifabutin (Mycobutin), rifampin (Rimactane, Rifadin, in Rifater); sirolimus (Rapamune); sotalol (Betapace); tacrolimus (Prograf); telithromycin (Ketek); thioridazine (Mellaril); and vandetanib (Caprelsa). Many other medications may also interact with crizotinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
tell your doctor what herbal products you are taking, especially St. John's wort.
tell your doctor if you have or have ever had long QT syndrome (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), a slow heartbeat, heart failure, or liver or kidney disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You should use birth control so that you or your partner will not become pregnant during your treatment with crizotinib and for 90 days after your treatment. Talk to your doctor about which method of birth control you should use. If you become pregnant while taking crizotinib, call your doctor immediately.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking crizotinib.
you should know that crizotinib may cause vision problems, dizziness, and excessive tiredness. Do not drive a car or operate machinery until you know how this medication affects you.