Prilosec (omeprazole) is a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is commonly used to treat conditions related to excess stomach acid, such as gastroesophageal reflux disease (GERD), erosive esophagitis, and stomach ulcers. Because omeprazole must be absorbed in order to be effective, it’s often recommended before meals for the prevention of symptoms, or on a consistent basis to promote healing of existing tissue damage. Antacids like Tums or Rolaids are often used for more immediate relief of infrequent heartburn.
GERD (Gastroesophageal Reflux Disease): Helps relieve heartburn, acid regurgitation, and inflammation caused by stomach acid backing up into the esophagus.
Erosive Esophagitis: Promotes healing of damage to the esophagus caused by acid.
H. pylori Infection: Used in combination with antibiotics to treat ulcers caused by Helicobacter pylori.
Frequent Heartburn: Over-the-counter (OTC) Prilosec is used to treat heartburn that occurs 2 or more days per week. Use should not exceed two weeks without medical supervision.
Prescription required. Can not be split. Product of New Zealand. Shipped from New Zealand. Prilosec is also marketed internationally under the name Losec.
Prescription required. Can not be split. Product of New Zealand. Shipped from New Zealand. Prilosec is also marketed internationally under the name Losec.
Prescription required. Can not be split. Product of New Zealand. Shipped from New Zealand. Prilosec is also marketed internationally under the name Losec.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom of Great Britain and Northern Ireland.
Prescription required. Can not be split. Product of New Zealand. Shipped from New Zealand.
Prescription required. Can not be split. Product of UK/EU. Shipped from United Kingdom of Great Britain and Northern Ireland.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Prilosec is prescribed for both short-term relief and long-term management of acid-related digestive conditions. By blocking acid production at the source (the proton pumps in the stomach lining), Prilosec:
Alleviates symptoms like heartburn and acid reflux
Promotes healing of ulcers and damaged esophageal tissue
Prevents ulcer recurrence
Helps manage chronic conditions where stomach acid contributes to discomfort and inflammation
It is often used when other acid-reducing medications (like antacids or H2 blockers) are not effective enough.
Take exactly as directed on the package or by your healthcare provider.
Prescription use: Usually once daily before a meal.
OTC Prilosec OTC: Taken once daily for 14 days. Do not use for more than 14 days without medical supervision. Wait at least 4 months before repeating a course.
Capsules should be swallowed whole. If you can’t swallow them, you may open the capsule and mix with applesauce—do not chew.
Some forms (powder) must be dissolved in water for oral or NG tube administration.
Use the full course of treatment, even if symptoms improve early.
Take as soon as remembered unless it’s near your next scheduled dose.
Do not double up on doses.
Symptoms may include confusion, drowsiness, blurred vision, increased heart rate, or nausea.
Call 1-800-222-1222 (Poison Help) in the US or 1-844-764-7669 in Canada, or seek emergency medical help.
Headache
Nausea, vomiting
Abdominal pain, gas, or bloating
Diarrhea
Cold-like symptoms (sore throat, sneezing)
Kidney problems: Decreased urination, fluid retention leading to swelling around feet/ankles, blood in urine
Infection-related diarrhea: Watery or bloody stools (omeprazole increases the risk of serious gastrointestinal infections caused by C. difficile)
Lupus-like symptoms: Joint pain, rash worsened by sunlight
Magnesium deficiency: Muscle cramps, irregular heartbeat
Seizures or signs of serious allergic reactions (rash, swelling, difficulty breathing)
Bone fractures: Increased risk of wrist, hip, or spine fractures with long-term use
B-12 Deficiency: May be more likely to occur with prolonged use over 3 years
Stomach growths (fundic gland polyps): Risk increases with long-term use
You are allergic to omeprazole or similar drugs (esomeprazole, pantoprazole, lansoprazole)
You’ve had severe allergic or kidney reactions to PPIs in the past
You are taking rilpivirine, a medication for HIV
Liver or kidney disease
Low magnesium levels
Osteoporosis or low bone density
Unexplained weight loss or ongoing stomach pain
Trouble swallowing or signs of GI bleeding (black stools, bloody vomit)
Long-term need for acid suppression
Generally considered safe, but consult your doctor before use.
Breastfeeding mothers should monitor infants for any signs of discomfort.
Store at room temperature (68–77°F / 20–25°C), away from heat and moisture.
Keep the bottle tightly closed and out of reach of children.
Do not store in bathrooms.
Dispose of unused medication properly through pharmacy take-back programs or according to local regulations.
Some medications may be affected by changes in stomach acidity or altered absorption when taken with Prilosec.
Tell your doctor if you’re taking:
Digoxin
Clopidogrel
Methotrexate
St. John's Wort
Antibiotics like amoxicillin, clarithromycin, or rifampin
CYP2C19 substrates (e.g., antidepressants like citalopram)
Also avoid taking antidiarrheal medications if you experience severe or bloody diarrhea while on Prilosec—speak to a doctor first.
Important: Always share a full list of all your current medications, vitamins, and supplements with your provider to avoid interactions.
Omeprazole (oh me' pray zol) Prilosec® Prilosec® OTC Zegerid® (as a combination product containing Omeprazole, Sodium Bicarbonate) Zegerid® OTC (as a combination product containing Omeprazole, Sodium Bicarbonate)
Prescription omeprazole is used alone or with other medications to treat gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and possible injury of the esophagus (the tube between the throat and stomach). Prescription omeprazole is used to treat the symptoms of GERD, allow the esophagus to heal, and prevent further damage to the esophagus. Prescription omeprazole is also used to treat conditions in which the stomach produces too much acid such as Zollinger-Ellison syndrome. Prescription omeprazole is also used to treat ulcers (sores in the lining of the stomach or intestine) and it is also used with other medications to treat and prevent the return of ulcers caused by a certain type of bacteria (H. pylori). Nonprescription (over-the-counter) omeprazole is used to treat frequent heartburn (heartburn that occurs at least 2 or more days a week). Omeprazole is in a class of medications called proton-pump inhibitors. It works by decreasing the amount of acid made in the stomach.
Prescription omeprazole comes as a delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) capsule, and packets of delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) granules for suspension (to be mixed with liquid) to take by mouth. Nonprescription (over-the-counter) omeprazole comes as a delayed-release capsule or tablet to take by mouth. The delayed-release capsules and the granules should be taken at least 1 hour before a meal. They are usually taken once a day before a meal but may be taken twice a day when used with other medications to eliminate H. pylori, or up to three times a day when used to treat conditions in which the stomach produces too much acid. The nonprescription delayed-release tablets or capsules are usually taken once a day in the morning at least 1 hour before eating for 14 days in a row. Additional 14-day treatments may be repeated once every 4 months if needed. To help you remember to take omeprazole, take it at around the same time(s) every day. Follow the directions on your prescription label or the package label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take omeprazole exactly as directed. Do not take more or less of it or take it more often or for a longer period of time than prescribed by your doctor or stated on the package. Tell your doctor if you have taken nonprescription omeprazole for a longer period of time than stated on the package. If you are taking the delayed-release tablets, swallow them whole with a full glass of water. Do not split, chew, or crush them or crush and mix them into food. Swallow the delayed-release capsules whole. If you have difficulty swallowing the delayed-release capsules, place one tablespoon of soft, cool applesauce in an empty bowl. Open the delayed-release capsule and carefully empty all the granules inside the capsule onto the applesauce. Mix the granules with the applesauce and swallow the mixture immediately with a glass of cool water. Do not chew or crush the granules. Do not store the applesauce/granule mixture for future use. If you are taking the powder for oral suspension, you will need to mix it with water before use. If you are using the 2.5-mg packet, place 1 teaspoonful (5 mL) of water in a container. If you are using the 10-mg packet, place 1 tablespoonful (15 mL) of water in a container. Add the contents of the powder packet and stir. Wait 2 to 3 minutes to allow the mixture to thicken, and stir the mixture again. Drink the entire mixture within 30 minutes. If any of the mixture is stuck to the container, pour more water into the container, stir and drink all the mixture immediately. The powder and the contents of the prescription delayed-release capsules can both be given through a feeding tube. If you have a feeding tube, ask your doctor how you should take the medication. Follow the directions carefully. Do not take nonprescription omeprazole for immediate relief of heartburn symptoms. It may take 1 to 4 days for you to feel the full benefit of the medication. Call your doctor if your symptoms get worse or do not improve after 14 days or if your symptoms return sooner than 4 months after you finish your treatment. Do not take nonprescription omeprazole for longer than 14 days or treat yourself with omeprazole more often than once every 4 months without talking to your doctor. Continue to take omeprazole even if you feel well. Do not stop taking prescription omeprazole without talking to your doctor. If your condition does not improve or gets worse, call your doctor. Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Before taking omeprazole, tell your doctor and pharmacist if you are allergic to omeprazole, dexlansoprazole (Dexilant), esomeprazole (Nexium), lansoprazole (Prevacid), pantoprazole (Protonix), rabeprazole (Aciphex), any other medications, or any of the ingredients in the omeprazole product you will be taking. Ask your pharmacist or check the package label for a list of the ingredients. tell your doctor if you are taking rilpivirine (Edurant, in Complera, Odefsey). Your doctor will probably tell you not to take omeprazole if you are taking this medication. tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antibiotics, including ampicillin (Principen, in Unasyn);anticoagulants ('blood thinners') such as warfarin (Coumadin); atazanavir (Reyataz); benzodiazepines such as diazepam (Valium); cilostazol (Pletal); clopidogrel (Plavix); cyclosporine (Neoral, Sandimmune); digoxin (Lanoxicaps, Lanoxin) disulfiram (Antabuse); diuretics ('water pills'); iron supplements; ketoconazole (Nizoral); methotrexate (Rheumatrex, Trexall), nelfinavir (Viracept); phenytoin (Dilantin); saquinavir (Invirase); tacrolimus (Prograf); and voriconazole (Vfend) and other prescription antifungal or anti-yeast medications. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. if you plan to take nonprescription omeprazole, tell your doctor if your heartburn has lasted 3 months or longer or if you have experienced any of the following symptoms: lightheadedness, sweating, or dizziness along with your heartburn; chest pain or shoulder pain; shortness of breath or wheezing; pain that spreads to your arms, neck, or shoulders; unexplained weight loss; nausea; vomiting, especially if the vomit is bloody; stomach pain; difficulty swallowing food or pain when you swallow food; or black or bloody stools. You may have a more serious condition that cannot be treated with nonprescription medication. tell your doctor if you are of Asian descent and if you have or have ever had a low level of magnesium in your blood or liver disease. if you are 50 years of age or older, ask your doctor if it is safe for you to take nonprescription or prescription omeprazole. The risk that you may develop a severe form of diarrhea caused by bacteria or that you may fracture your wrist, hip, or spine may be higher if you are an older adult. tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking omeprazole, call your doctor.
Unless your doctor tells you otherwise, continue your normal diet.
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Omeprazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: constipation gas nausea vomiting headache Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately, or get emergency medical help: rash hives itching swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs difficulty breathing or swallowing hoarseness irregular, fast, or pounding heartbeat excessive tiredness dizziness lightheadedness muscle spasms uncontrollable shaking of a part of the body seizures diarrhea with watery stools stomach pain fever People who take proton pump inhibitors such as omeprazole may be more likely to fracture their wrists, hips, or spine than people who do not take one of these medications. The risk is highest in people who take high doses of one of these medications or take them for one year or longer. Some people who take omeprazole for a long time may develop weakening of the stomach lining. Talk to your doctor about the risks of taking omeprazole. Omeprazole may cause other side effects. Call your doctor if you have any unusual problems while taking this medication. If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat, and moisture (not in the bathroom). It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
Keep all appointments with your doctor and the laboratory. Your doctor may order certain laboratory tests before and during your treatment, especially if you have severe diarrhea. Do not let anyone else take your medication. If you are taking prescription omeprazole, ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
The content on this page is for informational and educational purposes only and does not constitute professional medical advice. Patients should not use the information presented on this page for diagnosing a health-related issue or disease. Before taking any medication or supplements, patients should always consult a physician or qualified healthcare professional for medical advice or information about whether a drug is safe, appropriate or effective.