Nexavar (Sorafenib Tosylate)
(℞) Prescription required. May be split. Product of Canada. Shipped from Canada.
To comply with Canadian International Pharmacy Association regulations you are permitted to order a 3-month supply or the closest package size available based on your personal prescription. read more
Sorafenib Tosylate Information
(soe raf' e nib)
Before taking sorafenib,
- tell your doctor and pharmacist if you are allergic to sorafenib, any other medications, or any of the ingredients in sorafenib tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor if you have lung cancer and are receiving treatment with carboplatin (Paraplatin) and paclitaxel (Abraxane, Onxol, Taxol) or gemcitabine (Gemzar) and cisplatin (Platinol). Your doctor will probably tell you not to take sorafenib if you have lung cancer and you are receiving these medications.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: certain medications for arrhythmias such as amiodarone (Nexterone, Pacerone), dofetilide (Tikosyn), dronedarone (Multaq), procainamide, quinidine (in Nuedexta), and sotalol (Betapace, Sorine, Sotylize); anticoagulants (blood thinners) such as warfarin (Coumadin, Jantoven); carbamazepine (Equetro, Tegretol, Teril); dexamethasone; ibutilide (Corvert); irinotecan (Camptosar); neomycin; phenobarbital; phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); or rifampin (Rifadin, Rimactane). Many other medications may also interact with sorafenib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you have or have ever had high blood pressure, bleeding problems, chest pain, heart problems, QT prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death), low levels of potassium, calcium, or magnesium in your blood, an irregular heartbeat, heart failure, kidney problems other than kidney cancer, or liver problems other than liver cancer.
- tell your doctor if you are pregnant or plan to become pregnant. You will have to take a pregnancy test before starting treatment. If you are a woman who is able to become pregnant, you must use effective birth control during your treatment and for 6 months after your final dose. If you are male with a female partner who could become pregnant, you must use effective birth control during your treatment and for 3 months after your final dose. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking sorafenib, call your doctor immediately. Sorafenib may harm the fetus.
- tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while taking sorafenib and for 2 weeks after your final dose.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking sorafenib.
- skin redness
- hair loss
- dry or peeling skin
- loss of appetite
- dry mouth
- weight loss
- joint pain
- numbness, pain or tingling in hands or feet
- unusual bruising or bleeding
- black and/or tarry stools
- red blood in stools
- bloody vomit
- vomiting material that looks like coffee grounds
- severe stomach pain
- chest pain
- shortness of breath
- dizziness or fainting
- excessive sweating
- fast, pounding, or irregular heartbeat
- sudden severe headache
- changes in vision
- redness, pain, swelling or blisters on the palms of the hands or soles of the feet
- skin blistering and peeling
- skin redness
- mouth sores
- dark urine
- yellowing of the skin or eyes
- pain in the upper right part of the stomach