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(vis'' moe deg' ib)For all patients: Vismodegib should not be taken by women who are pregnant or who may become pregnant. There is a risk that vismodegib will cause loss of the pregnancy or will cause the baby to be born with birth defects (physical problems that are present at birth). Do not donate blood while you are taking vismodegib and for 7 months after your treatment. Do not share vismodegib with anyone else, even someone who has the same symptoms you have. Talk to your doctor about the risk(s) of taking vismodegib. For female patients: If you can become pregnant, you will need to avoid becoming pregnant during your treatment with vismodegib. You must have a negative pregnancy test within 1 week of the start of your treatment. You must use acceptable forms of birth control during your treatment and for 7 months after your treatment is completed. Your doctor will tell you which forms of birth control are acceptable. If you think you are pregnant, you miss a menstrual period, or you have sex without using birth control while taking vismodegib or within 7 months after your treatment, call your doctor immediately. For male patients: You must use a condom every time you have sexual contact with a female who is pregnant or able to become pregnant while you are taking vismodegib and for 3 months after your treatment. This is required even if you have had a vasectomy (surgery to prevent sperm from leaving your body and causing pregnancy). Tell your doctor immediately if you have had unprotected sex with a woman who can become pregnant or if you think for any reason that your partner is pregnant. Do not donate semen while you are taking vismodegib and for 3 months after your treatment.
Before taking vismodegib,
- tell your doctor and pharmacist if you are allergic to vismodegib, any other medications, or any of the ingredients in vismodegib capsules. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: antacids; certain antibiotics such as azithromycin (Z-Pak, Zithromax), clarithromycin (Biaxin, in Prevpac), and erythromycin (E.E.S., Eryc, Ery-Tab, Erythrocin, PCE); a medication for indigestion, heartburn, or ulcers such as cimetidine (Tagamet), famotidine (Pepcid), and ranitidine (Zantac); and proton-pump inhibitors such as dexlansoprazole (Dexilant), lansoprazole (Prevacid, in Prevpac), omeprazole (Prilosec, Zegerid), pantoprazole (Protonix), and rabeprazole (AcipHex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with vismodegib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- do not breast-feed while you are taking vismodegib and for 7 months after your treatment.
- muscle spasms
- joint pain
- hair loss
- change in how things taste or loss of taste
- decreased appetite
- weight loss
- missed menstrual periods