Bosulif (Bosutinib Monohydrate)
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Bosutinib Monohydrate Information
(boe sue' ti nib)
Before taking bosutinib,
- tell your doctor and pharmacist if you are allergic to bosutinib or any of the ingredients in bosutinib tablets. Ask your pharmacist for a list of the ingredients.
- tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: certain antifungals such as ketoconazole and itraconazole (Sporanox); aprepitant (Emend); certain medications used to treat human immunodeficiency virus (HIV) such as indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir), and saquinavir (Invirase); medications to reduce stomach acid (proton-pump inhibitors) such as esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), and rabeprazole (AcipHex); diltiazem (Cardizem, Cartia, Tiazac); erythromycin (E.E.S., E-Mycin, Erythrocin); nefazodone; rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane in Rifamate, in Rifater). Many other medications may also interact with bosutinib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- if you are taking antacids, such as aluminum hydroxide/magnesium hydroxide (Maalox), calcium carbonate (Tums) or calcium carbonate and magnesium (Rolaids) or medications to reduce stomach acid, such as cimetidine (Tagamet), famotidine (Pepcid), or ranitidine (Zantac), take them 2 hours before or 2 hours after you take bosutinib.
- tell your doctor what herbal products you are taking, especially St. John's wort.
- tell your doctor if you have or have ever had kidney, liver, or heart disease.
- tell your doctor if you are pregnant or plan to become pregnant. You will need to take a pregnancy test before you start treatment and you should not become pregnant while you are taking bosutinib. You should use an effective form of birth control during treatment with bosutinib and for 2 weeks after your final dose. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking bosutinib, call your doctor. Bosutinib may harm the fetus.
- tell your doctor if you are breastfeeding. You should not breastfeed while you are taking bosutinib and for 2 weeks after your last dose.
- you should know that this medication may decrease fertility in men and women. Talk to your doctor about the risks of taking bosutinib.
- loss of appetite
- tiredness or weakness
- change in ability to taste food
- ringing in the ears
- sudden stomach area pain
- unexplained bleeding or bruising
- blood in urine or stool
- change in the frequency of urination
- increase or decrease in the amount of urine
- fever, sore throat, chills, or other signs of infection
- shortness of breath and cough
- chest pain
- swelling of face, hands, ankles, feet, or lower legs
- sudden weight gain
- yellowing of the skin and eyes
- dark or tea-colored urine
- difficulty breathing or swallowing