Tagrisso (Osimertinib) is an oral prescription medication used to treat non-small cell lung cancer (NSCLC) with specific epidermal growth factor receptor (EGFR) mutations. It works as a third-generation EGFR tyrosine kinase inhibitor (TKI), blocking the activity of mutant EGFR proteins that drive cancer growth. Tagrisso is typically taken once daily and may be used as a first-line treatment or in patients whose cancer has progressed on earlier EGFR therapies.
Without insurance, Tagrisso (Osimertinib) can be costly, with U.S. retail pharmacy prices for 40 mg tablets averaging $5,868–$5,881 for a 30-day supply.
Key Takeaways
Online Pharmacies Offer Significant Savings: CIPA-certified international pharmacies like DrugMart list Tagrisso (Osimertinib) at $31,710.88 for a 90-tablet supply—saving more than 40% compared to U.S. retail pharmacies.
U.S. Pharmacies Charge $5,868–$5,881 Monthly Without Insurance: Retailers such as Walgreens and CVS list Tagrisso (Osimertinib) at approximately $587–$588 per tablet for the 40 mg strength.
Tagrisso Is Covered by Medicare and Private Insurance: It is usually placed on Tier 5 (specialty tier) and often requires prior authorization.
Cheapest Online Pharmacies for Tagrisso (Osimertinib)
Pharmacy | Prescription Required | Price | Dosage | Supply | Price per Tablet | Website |
DrugMart | Yes | $31,710.88 | 40 mg | 90 tablets | $352.34 | |
Planet Drugs Direct | Yes | $43,139.99 | 40 mg | 90 tablets | $479.33 | |
Blink Health | Yes | $17,360.88 | 40 mg | 30 tablets | $578.70 |
Prices as of August 15 2025. May vary by quantity, shipping origin, and dosage strength.
U.S. Retail Prices for Tagrisso (Osimertinib)
Pharmacy | Retail Price (30-Day Supply) |
Walgreens | $5,868.97 |
CVS Pharmacy | $5,881.42 |
CVS Inside Target | $5,881.42 |
Prices as of August 15 2025. Actual costs may vary by location and insurance status.
How to Save on Tagrisso (Osimertinib)
1. Use Medicare Part D or Commercial Insurance
Tagrisso is covered by most Medicare Part D and commercial insurance plans, though it is typically placed on a high-cost specialty tier (Tier 5). The coinsurance rate can range from 25% to 33% unless capped by the Medicare 2025 $2,000 out-of-pocket maximum. Tip: Use the Medicare Plan Finder or your insurance portal to estimate actual out-of-pocket costs.
2. Manufacturer Co-pay and Patient Assistance Programs
AstraZeneca Access 360®
For commercially insured patients: May pay as little as $0 per month
Patient assistance available for uninsured or underinsured patients meeting eligibility requirements
Phone: 1-844-ASK-A360 (1-844-275-2360)
Website: access360.com
3. CIPA-Certified Online Pharmacies
Purchasing from licensed international pharmacies can lower costs by over 40%. A valid prescription is required, and medications ship from regulated facilities in Australia or Canada.
Common Questions About Tagrisso (Osimertinib)
1. Is Tagrisso covered by Medicare?
Yes. Most Medicare Part D and Advantage plans list Tagrisso (Osimertinib) on their formularies, typically on a specialty tier with prior authorization.
2. Can I use the Tagrisso co-pay program with Medicare?
No. Manufacturer co-pay programs generally exclude Medicare and Medicaid beneficiaries, though nonprofit assistance programs may help.
3. How much will Tagrisso (Osimertinib) cost per year?
Purchase Method | Monthly Estimate | Annual Estimate |
U.S. Retail Pharmacies | $5,868 – $5,881 | $70,416 – $70,572 |
CIPA Online Pharmacy (DrugMart) | ~$10,570* | ~$31,710* |
Medicare Part D (2025 cap) | Max $2,000/year | $2,000 |
AstraZeneca Co-pay Program | As low as $0 | Varies (max benefit applies) |
*Based on the prorated cost of a 90-tablet supply from DrugMart.
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