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(dye kloe' fen ak)People who use nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as transdermal diclofenac may have a higher risk of having a heart attack or a stroke than people who do not use these medications. These events may happen without warning and may cause death. The risk may be higher for people who use NSAIDs for a long time. Do not use an NSAID such as transdermal diclofenac if you have recently had a heart attack, unless directed to do so by your doctor. Tell your doctor if you or anyone in your family has or has ever had heart disease, a heart attack, or a stroke; if you smoke; and if you have or have ever had high cholesterol, high blood pressure, or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of your body, or slurred speech. If you will be undergoing a coronary artery bypass graft (CABG; a type of heart surgery), you should not use transdermal diclofenac right before or right after the surgery. NSAIDs such as transdermal diclofenac may cause swelling, ulcers, bleeding, or holes in the stomach or intestines. These problems may develop at any time during treatment, may happen without warning symptoms, and may cause death. The risk may be higher for people who use NSAIDs for a long time, are older in age, have poor health, smoke, or drink alcohol while using transdermal diclofenac . Tell your doctor if you have any of these risk factors and if you have or have ever had ulcersor bleeding in your stomach or intestines, or other bleeding disorders. Tell your doctor if you take any of the following medications: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ibuprofen (Advil, Motrin) or naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). If you experience any of the following symptoms, stop using transdermal diclofenac and call your doctor: stomach pain, heartburn, vomiting a substance that is bloody or looks like coffee grounds, blood in the stool, or black and tarry stools. Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably take your blood pressure and order certain tests to check your body's response to transdermal diclofenac. Be sure to tell your doctor how you are feeling so that the doctor can prescribe the right amount of medication to treat your condition with the lowest risk of serious side effects.
- Wash the skin area where you will apply the patch with soap and water. Do not use any moisturizing soaps, lotions, astringents, or other skin care products on the chosen skin area.
- Completely dry the skin area where you will be applying the patch.
- Cut open the envelope containing the patches, cutting on the dotted line and making sure not to cut the zipper seal just below it.
- Pull apart the zipper seal on the envelope and remove one patch. Reseal the envelope by squeezing the zipper seal together. Make sure the envelope is closed tightly to keep the patches inside from drying out.
- Fold over one corner of the patch and gently rub the folded corner between your finger and thumb to separate the patch from the clear liner that is attached to the sticky side. Peel off the entire liner.
- Firmly press the patch into place on the chosen skin area. Press down around all four edges to secure the patch.
- The patch may begin to peel off while you are wearing it. If this happens, tape down the edges of the patch with first aid tape.
- When you remove a patch, fold it in half so that it sticks to itself and throw it away in a garbage can that is out of the reach of children and pets.
- Wash your hands when you are finished applying or handling the patch.
Before using diclofenac patches,
- tell your doctor and pharmacist if you are allergic to diclofenac (Cambia, Pennsaid, Solaraze, Voltaren, Zipsor, Zorvolex, in Arthrotec), aspirin, or other NSAIDs; any other medications; or any of the other ingredients in diclofenac patches. Ask your pharmacist or check the Medication Guide for a list of the ingredients. Tell your doctor and pharmacist if you have asthma, growths in your nose, or an ongoing runny nose and if you have had an asthma attack, hives, difficulty breathing or swallowing, or an allergic reaction after taking aspirin, an aspirin-containing product, or any other NSAID medication. Your doctor will probably tell you not to use diclofenac patches.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: acetaminophen (Tylenol, other products); angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril (in Zestoretic), moexipril (Univasc, in Uniretic); perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace), and trandolapril (Mavik, in Tarka); angiotensin receptor blockers such as candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor), telmisartan (Micardis, in Micardis HCT, in Twynsta), and valsartan (in Exforge HCT); certain antibiotics; beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal, Innopran); cyclosporine (Gengraf, Neoral, Sandimmune); diuretics ('water pills'); lithium (Lithobid); medications for seizures; and methotrexate (Otrexup, Rasuvo, Trexall). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
- tell your doctor if you have severe diarrhea or vomiting or think you may be dehydrated, if you drink or have a history of drinking large amounts of alcohol, and if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section, heart failure; swelling of the hands, feet, ankles, or lower legs; or kidney or liver disease.
- tell your doctor if you are pregnant, especially if you are in the last few months of your pregnancy, you plan to become pregnant, or you are breast-feeding. If you become pregnant while using diclofenac patches, call your doctor.
- if you are having surgery, including dental surgery, tell the doctor or dentist that you are using diclofenac patches.
- you should know that during treatment with diclofenac patches it may be harder to know if you have an infection or illness because this medication may also lower or prevent fever. Call your doctor if you are not feeling well or have other signs of an infection or illness.
- dryness, redness, itching, swelling, irritation, or numbness at application site
- changes in taste
- tingling skin
- difficulty swallowing
- swelling of the face or throat, arms, or hands
- unexplained weight gain
- shortness of breath or difficulty breathing
- swelling in the abdomen, ankles, feet, or legs
- worsening of asthma
- yellowing of the skin or eyes
- extreme tiredness
- unusual bleeding or bruising
- lack of energy
- loss of appetite
- pain in the upper right part of the stomach
- flu-like symptoms
- dark-colored urine
- blisters on skin
- pale skin
- fast heartbeat